在科威特，引起侵袭性疾病的肺炎链球菌的血清型分布和青霉素不敏感性：10 年研究肺炎球菌结合疫苗的影响。
Serotype distribution and penicillin-non-susceptibility of Streptococcus pneumoniae causing invasive diseases in Kuwait: A 10-year study of impact of pneumococcal conjugate vaccines.
机构信息
a Faculty of Medicine, Department of Microbiology , Kuwait University , Jabriya , Kuwait.
出版信息
Expert Rev Vaccines. 2016 Oct;15(10):1337-45. doi: 10.1080/14760584.2016.1198698. Epub 2016 Jun 24.
OBJECTIVES
The impact of PCV7 and PCV13 on pneumococcal infections in Kuwait is not known. Therefore we evaluated the impact on pneumococcal serotype distribution and penicillin-non-susceptibility in invasive infections in Kuwait.
METHODS
Children < 2 y were given PCV7 from Aug 2006 to Jul 2010 (period I), and PCV13 from Aug 2010 to Jul 2013 (period II) with a pre-vaccination period from Aug 2003 to Jul 2006. Serotype and penicillin-non-susceptibility of blood and cerebrospinal fluid isolates from all ages were determined.
RESULTS
In <2 y old children, even with a small number of infections, a drop in PCV7 serotypes was evident after vaccination. For all age groups combined, in the pre-vaccination period, PCV7, PCV13, PCV13 non-PCV7 serotypes and penicillin-non-susceptibility constituted 53.2%, 72.6%, 19.4% and 6.5% of the isolates respectively. PCV7, PCV13 non-PCV7 serotypes and penicillin-non-susceptibility changed to 32.7%, 28.2% and 7.3% (period I) and 6.6%, 22.2% and 8.9% (period II).
CONCLUSIONS
Vaccines reduced invasive infections due to PCV7 serotypes.
目的
尚不清楚 7 价肺炎球菌结合疫苗（PCV7）和 13 价肺炎球菌结合疫苗（PCV13）对科威特肺炎球菌感染的影响。因此，我们评估了它们对科威特侵袭性感染中肺炎球菌血清型分布和青霉素不敏感的影响。
方法
2 岁以下儿童于 2006 年 8 月至 2010 年 7 月（第 I 期）接种 PCV7，于 2010 年 8 月至 2013 年 7 月（第 II 期）接种 PCV13，同时于 2003 年 8 月至 2006 年 7 月设立疫苗接种前阶段。对所有年龄段的血液和脑脊液分离株的血清型和青霉素不敏感性进行了检测。
结果
在 2 岁以下儿童中，即使感染例数较少，疫苗接种后 PCV7 血清型也明显下降。对于所有年龄组，在疫苗接种前阶段，PCV7、PCV13、PCV13 非 PCV7 血清型和青霉素不敏感性分别占分离株的 53.2%、72.6%、19.4%和 6.5%。PCV7、PCV13 非 PCV7 血清型和青霉素不敏感性分别转变为 32.7%、28.2%和 7.3%（第 I 期）和 6.6%、22.2%和 8.9%（第 II 期）。
结论
疫苗减少了 PCV7 血清型引起的侵袭性感染。
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