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正常妊娠与妊娠期缺铁性贫血患者血清促红细胞生成素、转铁蛋白受体、铁蛋白水平及其他血液学指标的横断面比较研究。

Cross sectional, comparative study of serum erythropoietin, transferrin receptor, ferritin levels and other hematological indices in normal pregnancies and iron deficiency anemia during pregnancy.

作者信息

Sharma Jai B, Bumma Sirisha D, Saxena Renu, Kumar Sunesh, Roy Kallol K, Singh Neeta, Vanamail P

机构信息

Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2016 Aug;203:99-103. doi: 10.1016/j.ejogrb.2016.05.022. Epub 2016 May 20.

DOI:10.1016/j.ejogrb.2016.05.022

PMID:27267870

Abstract

OBJECTIVE

To test the correlation of the serum erythropoietin levels, serum transferrrin receptor levels and serum ferritin levels along with other hematological parameters in normal pregnant and anemic pregnant patients.

STUDY DESIGN

In a prospective study, 120 pregnant women were recruited between 18 and 36 weeks of gestation; 53 normal pregnant patients, 67 anemic pregnant patients, in which, 17 had mild, 30 had moderate anemia, 20 had severe anemia. A blood sample was taken. The various hematological parameters, hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), total iron binding capacity (TIBC), serum ferritin, percentage saturation of iron, serum erythropoietin (SEPO) levels, serum transferrin receptors (STfRS) were performed. For statistics, Student's 't' test, Pearson's Chi test, Mann Whitney test and Bartlett test were used as per data.

RESULTS AND CONCLUSION

MCV was significantly reduced in anemic pregnancies as compared to non-anemic pregnancies (80.2±9.6 vs 94.12±9.8fl, p=0.001), MCHC was also reduced in them (30.2±3.38% vs 34.2±2.33%, p=0.176), TIBC was significantly increased in anemic pregnancies (343.31±28.54% vs 322.88±23.84%, p=0.001), serum ferritin was significantly reduced (24.9±10.48μg/L vs 31.03±9.98μg/L, p=0.001), percentage saturation of iron was also reduced (53.85±13.21% vs 62.04±15.79%, p=0.0024), serum erythropoietin levels were significantly higher in anemic women (26.24±26.61mU/ml vs 18.12±19.08mU/ml, p=0.064). The levels were significantly higher in severe anemia (46.5±46.8mU/ml than in moderate anemia 27.4±28.1mU/ml and mild anemia 22.8±22.8mU/ml. Serum transferrin receptors were significantly higher in anemic pregnancies than in non-anemic pregnancies (1.40±0.0802μg/ml vs 1.08±0.641μg/ml, p=0.019) with rise being higher in severe anemia (2.28±0.986μg/ml) than in moderate (1.4±0.816μg/ml) and mild anemia (1.16±0.702μg/ml).

CONCLUSION

Various hematological parameters especially sTfR, serum erythropoietin, serum ferritin and sTfR/log ferritin levels correlate with the severity of anemia.

摘要

目的

检测正常孕妇和贫血孕妇血清促红细胞生成素水平、血清转铁蛋白受体水平、血清铁蛋白水平与其他血液学参数之间的相关性。

研究设计

在一项前瞻性研究中，招募了120名妊娠18至36周的孕妇；53名正常孕妇，67名贫血孕妇，其中17名轻度贫血，30名中度贫血，20名重度贫血。采集血样。检测了各种血液学参数，包括血红蛋白（Hb）、平均红细胞体积（MCV）、平均红细胞血红蛋白浓度（MCHC）、总铁结合力（TIBC）、血清铁蛋白、铁饱和度百分比、血清促红细胞生成素（SEPO）水平、血清转铁蛋白受体（STfRS）。统计分析时，根据数据分别采用了学生t检验、Pearson卡方检验、Mann-Whitney检验和Bartlett检验。

结果与结论

与非贫血妊娠相比，贫血妊娠的MCV显著降低（80.2±9.6 vs 94.12±9.8fl，p = 0.001），MCHC也降低（30.2±3.38% vs 34.2±2.33%，p = 0.176），贫血妊娠的TIBC显著升高（343.31±28.54% vs 322.88±23.84%，p = 0.001），血清铁蛋白显著降低（24.9±10.48μg/L vs 31.03±9.98μg/L，p = 0.001），铁饱和度百分比也降低（53.85±13.21% vs 62.04±15.79%，p = 0.0024），贫血女性的血清促红细胞生成素水平显著升高（26.24±26.61mU/ml vs 18.12±19.08mU/ml，p = 0.064）。重度贫血患者的该水平（46.5±46.8mU/ml）显著高于中度贫血患者（27.4±28.1mU/ml）和轻度贫血患者（22.8±22.8mU/ml）。贫血妊娠的血清转铁蛋白受体显著高于非贫血妊娠（1.40±0.0802μg/ml vs 1.08±0.641μg/ml，p = 0.019），重度贫血患者（2.28±0.986μg/ml）的升高幅度高于中度贫血患者（1.4±0.816μg/ml）和轻度贫血患者（1.16±0.702μg/ml）。