激肽释放酶对支持细胞功能的影响。

Effect of kallikrein on the Sertoli cell function.

作者信息

Saito S, Mikuma N, Kumamoto Y

机构信息

Department of Urology, Sapporo Medical College, Japan.

出版信息

Urol Int. 1989;44(2):87-9. doi: 10.1159/000281477.

DOI:10.1159/000281477

PMID:2728131

Abstract

The effect of kallikrein on the Sertoli cells was investigated to determine the rat testicular androgen binding component (ABC = androgen binding protein + androgen receptor) concentration using the dextran-coated charcoal method. The results showed that the concentrations of testicular ABC were increased significantly by the administration of kallikrein to levels approaching those seen after stimulation by LH-RH or FSH. Therefore, it is suggested that kallikrein has an effect that influences the Sertoli cells directly or indirectly.

摘要

使用葡聚糖包被活性炭法研究了激肽释放酶对支持细胞的作用，以确定大鼠睾丸雄激素结合成分（ABC = 雄激素结合蛋白 + 雄激素受体）的浓度。结果表明，给予激肽释放酶后，睾丸ABC的浓度显著升高，接近促黄体激素释放激素（LH-RH）或促卵泡激素（FSH）刺激后的水平。因此，提示激肽释放酶具有直接或间接影响支持细胞的作用。