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默认网络与衰老：超越任务负性视角

Default Network and Aging: Beyond the Task-Negative Perspective.

作者信息

Maillet David, Schacter Daniel L

机构信息

Department of Psychology and Center for Brain Science, Harvard University, Cambridge, MA, USA.

Department of Psychology and Center for Brain Science, Harvard University, Cambridge, MA, USA.

出版信息

Trends Cogn Sci. 2016 Sep;20(9):646-648. doi: 10.1016/j.tics.2016.05.009. Epub 2016 Jun 6.

DOI:10.1016/j.tics.2016.05.009
PMID:27282744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4992615/
Abstract

During cognitive tasks requiring externally directed attention, activation in the default-network (DN) typically decreases below baseline levels ('deactivation'). Healthy aging is associated with reduced deactivation, which is usually attributed to a failure to suppress DN processes. Recent evidence instead suggests that older adults may be more reliant on DN than young adults when performing these tasks.

摘要

在需要外部定向注意力的认知任务期间，默认网络（DN）中的激活通常会降至基线水平以下（“失活”）。健康衰老与失活减少有关，这通常归因于无法抑制DN过程。相反，最近的证据表明，老年人在执行这些任务时可能比年轻人更依赖DN。

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[6]
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本文引用的文献

[1]
When the mind wanders: Distinguishing stimulus-dependent from stimulus-independent thoughts during incidental encoding in young and older adults.

Psychol Aging. 2016-6

[2]
Assessing the Neural Correlates of Task-unrelated Thoughts during Episodic Encoding and Their Association with Subsequent Memory in Young and Older Adults.

J Cogn Neurosci. 2016-6

[3]
From mind wandering to involuntary retrieval: Age-related differences in spontaneous cognitive processes.

Neuropsychologia. 2016-1-8

[4]
Prefrontal Engagement and Reduced Default Network Suppression Co-occur and Are Dynamically Coupled in Older Adults: The Default-Executive Coupling Hypothesis of Aging.

J Cogn Neurosci. 2015-12

[5]
Neural compensation in older people with brain amyloid-β deposition.

Nat Neurosci. 2014-10

[6]
Age-related differences in brain activity in the subsequent memory paradigm: a meta-analysis.

Neurosci Biobehav Rev. 2014-9

[7]
The role of default network deactivation in cognition and disease.

Trends Cogn Sci. 2012-11-8

[8]
Aβ Deposition in aging is associated with increases in brain activation during successful memory encoding.

Cereb Cortex. 2011-9-23

[9]
Amyloid deposition is associated with impaired default network function in older persons without dementia.

Neuron. 2009-7-30

[10]
The relationship between aging, performance, and the neural correlates of successful memory encoding.

Cereb Cortex. 2009-3

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