小儿白血病的进展与展望

Progress and Prospects in Pediatric Leukemia.

作者信息

Madhusoodhan P Pallavi, Carroll William L, Bhatla Teena

机构信息

Division of Pediatric Hematology Oncology, Department of Pediatrics, Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY.

出版信息

Curr Probl Pediatr Adolesc Health Care. 2016 Jul;46(7):229-241. doi: 10.1016/j.cppeds.2016.04.003. Epub 2016 Jun 6.

DOI:10.1016/j.cppeds.2016.04.003

PMID:27283082

Abstract

Pediatric leukemia is the single most common malignancy affecting children, representing up to 30% of all pediatric cancers. Dramatic improvements in survival for acute lymphoblastic leukemia (ALL) have taken place over the past 4 decades with outcomes approaching 90% in the latest studies. However, progress has been slower for myeloid leukemia and certain subgroups like infant ALL, adolescent/young adult ALL, and relapsed ALL. Recent advances include recognition of molecularly defined subgroups, which has ushered in precision medicine approaches. We discuss the current understanding of the biology of the various childhood leukemias, recent advances in research, and future challenges in this field.

摘要

小儿白血病是影响儿童的最常见单一恶性肿瘤，占所有小儿癌症的30%。在过去40年里，急性淋巴细胞白血病（ALL）的生存率有了显著提高，最新研究中的生存率接近90%。然而，髓系白血病以及某些亚组，如婴儿ALL、青少年/青年ALL和复发性ALL的进展较为缓慢。最近的进展包括对分子定义亚组的认识，这带来了精准医学方法。我们讨论了目前对各种儿童白血病生物学的理解、研究的最新进展以及该领域未来的挑战。