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山茱萸环烯醚萜苷对不同年龄SAMP8小鼠行为损伤和衰老状态的有益作用。

Beneficial effects of cornel iridoid glycoside on behavioral impairment and senescence status in SAMP8 mice at different ages.

作者信息

Ma Denglei, Zhu Yanqiu, Li Yanzheng, Yang Cuicui, Zhang Li, Li Yali, Li Lin, Zhang Lan

机构信息

Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing Institute for Brain Disorders, Beijing Engineering Research Center for Nerve System Drugs, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China.

Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing Institute for Brain Disorders, Beijing Engineering Research Center for Nerve System Drugs, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China.

出版信息

Behav Brain Res. 2016 Oct 1;312:20-9. doi: 10.1016/j.bbr.2016.06.008. Epub 2016 Jun 6.

Abstract

The aim of the present study was to investigate the effects of cornel iridoid glycoside (CIG) on behavioral changes and senescent status in senescence-accelerated mouse-prone 8 (SAMP8) mice at different ages (6, 10, and 14 months old). The learning and memory ability, the motor function and the aging conditions of SAMP8 mice were evaluated after CIG treatment in this study. Results showed that intragastrical administration of CIG (100 and 200mg/kg) for two months obviously improved the impaired cognitive ability of SAMP8 mice at the age of 6 months and 10 months, respectively. The treatment with CIG significantly increased the motor function of SAMP8 mice at 10 months and 14 months of age, respectively. CIG also evidently decreased the high grading score of senescence and increased the low surviving rate of SAMP8 mice at the age of 14 months. In addition, CIG treatment inhibited tau hyperphosphorylation in the hippocampus and striatum of SAMP8 mice at different ages. Together, these results indicate that CIG represent a potentially useful treatment for ameliorating the impaired cognitive ability, the motor dysfunction, aging conditions and hyperphosphorylation of tau in aging and age-related neurodegenerative diseases, such as Alzheimer's disease.

摘要

本研究的目的是探讨山茱萸环烯醚萜苷(CIG)对不同年龄(6、10和14月龄)的快速老化小鼠8(SAMP8)行为变化和衰老状态的影响。本研究在CIG处理后评估了SAMP8小鼠的学习和记忆能力、运动功能及衰老情况。结果显示,连续两个月胃内给予CIG(100和200mg/kg)分别显著改善了6月龄和10月龄SAMP8小鼠受损的认知能力。CIG处理分别显著提高了10月龄和14月龄SAMP8小鼠的运动功能。CIG还明显降低了14月龄SAMP8小鼠的高等级衰老评分并提高了低存活率。此外,CIG处理抑制了不同年龄SAMP8小鼠海马体和纹状体中tau蛋白的过度磷酸化。总之,这些结果表明,CIG可能是一种有效的治疗方法,可改善衰老及与年龄相关的神经退行性疾病(如阿尔茨海默病)中受损的认知能力、运动功能障碍、衰老情况及tau蛋白的过度磷酸化。

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