Xu Xiao-Ming, Ni Xiao-Bing, Yang Gong-Li, Luo Zhi-Guo, Niu Yu-Ming, Shen Ming
Department of Stomatology and Center for Evidence-Based Medicine and Clinical Research, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China; Department of Gastroenterology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
Department of Gastroenterology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China.
Mol Clin Oncol. 2016 Jun;4(6):1078-1084. doi: 10.3892/mco.2016.844. Epub 2016 Apr 4.
Molecular epidemiological studies have revealed a closer association between cyclin D1 (CCND1) polymorphism and the risk of colorectal cancer; however, the results were inconsistent. The aim of the present meta-analysis was to investigate the association between CCND1 G870A polymorphism and colorectal cancer risk. Online electronic databases (PubMed and Embase) were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between CCND1 G870A polymorphism and the risk of colorectal cancer. In addition, heterogeneity, publication bias and sensitivity analysis were performed to guarantee the statistical power. In total, 23 published case-control studies with 6,320 patients and 8,252 controls were selected. Significantly increased risks were observed in four genetic models (A vs. G: OR=1.09, 95% CI=1.00-1.18, =54.3%; GA vs. GG: OR=1.13, 95% CI=1.04-1.24, =18.2%; AA vs. GG, OR=1.17: 95% CI=1.00-1.38, =52.5%; GA+AA vs. GG: OR=1.14, 95% CI=1.05-1.24, =33.8%). Similarly, significant associations were also identified in the stratified analysis in the cancer subtype of sporadic colorectal cancer (GA vs. GG: OR=1.21, 95% CI=1.04-1.42, =24.1%; GA+AA vs. GG: OR=1.18, 95% CI=1.02-1.37, =35.0%), Caucasian population (GA vs. GG, OR=1.14, 95% CI=1.02-1.28, =19.8%; GA+AA vs. GG, OR=1.14, 95% CI=1.02-1.27, =37.5%) and other subgroups of control design and genotyping type. The present updated meta-analysis suggested that CCND1 G870A may present an increased risk for developing colorectal cancer, particularly in sporadic colorectal cancer and a Caucasian population.
分子流行病学研究显示细胞周期蛋白D1（CCND1）基因多态性与结直肠癌风险之间存在更密切的关联；然而，结果并不一致。本荟萃分析的目的是研究CCND1 G870A基因多态性与结直肠癌风险之间的关联。检索了在线电子数据库（PubMed和Embase）。计算比值比（OR）及95%置信区间（CI）以评估CCND1 G870A基因多态性与结直肠癌风险之间的关联。此外，进行了异质性、发表偏倚和敏感性分析以确保统计效力。总共选取了23项已发表的病例对照研究，涉及6320例患者和8252例对照。在四种遗传模型中观察到风险显著增加（A与G相比：OR = 1.09，95% CI = 1.00 - 1.18，P = 54.3%；GA与GG相比：OR = 1.13，95% CI = 1.04 - 1.24，P = 18.2%；AA与GG相比，OR = 1.17：95% CI = 1.00 - 1.38，P = 52.5%；GA + AA与GG相比：OR = 1.14，95% CI = 1.05 - 1.24，P = 33.8%）。同样，在散发性结直肠癌的癌症亚型分层分析中（GA与GG相比：OR = 1.21，95% CI = 1.04 - 1.42, P = 24.1%；GA + AA与GG相比：OR = 1.18，95% CI = 1.02 - 1.37，P = 35.0%）、白种人群（GA与GG相比，OR = 1.14，95% CI = 1.02 - 1.28, P = 19.8%；GA + AA与GG相比，OR = 1.14，95% CI = 1.02 - 1.27，P = 37.5%）以及对照设计和基因分型类型的其他亚组中也发现了显著关联。本最新荟萃分析表明，CCND1 G870A可能会增加患结直肠癌的风险，尤其是在散发性结直肠癌和白种人群中。
