Pai Vishwas D, Engineer Reena, Patil Prachi S, Arya Supreeta, Desouza Ashwin L, Saklani Avanish P
1 Departmentof Surgical Oncology, 2 Departmentof Radiation Oncology, 3 Department of Digestive Diseases and Clinical Nutrition, 4 Departmentof Radio diagnosis, Tata Memorial Centre, Mumbai, Maharashtra 400012, India.
J Gastrointest Oncol. 2016 Jun;7(3):354-9. doi: 10.21037/jgo.2015.11.05.
To compare extra levator abdomino perineal resection (ELAPER) with conventional abdominoperineal resection (APER) in terms of short-term oncological and clinical outcomes.
This is a retrospective review of a prospectively maintained database including all the patients of rectal cancer who underwent APER at Tata Memorial Center between July 1, 2013, and January 31, 2015. Short-term oncological parameters evaluated included circumferential resection margin involvement (CRM), tumor site perforation, and number of nodes harvested. Peri operative outcomes included blood loss, length of hospital stay, postoperative perineal wound complications, and 30-day mortality. The χ(2)-test was used to compare the results between the two groups.
Forty-two cases of ELAPER and 78 cases of conventional APER were included in the study. Levator involvement was significantly higher in the ELAPER compared with the conventional group; otherwise, the two groups were comparable in all the aspects. CRM involvement was seen in seven patients (8.9%) in the conventional group compared with three patients (7.14%) in the ELAPER group. Median hospital stay was significantly longer with ELAPER. The univariate analysis of the factors influencing CRM positivity did not show any significance.
ELAPER should be the preferred approach for low rectal tumors with involvement of levators. For those cases in which levators are not involved, as shown in preoperative magnetic resonance imaging (MRI), the current evidence is insufficient to recommend ELAPER over conventional APER. This stresses the importance of preoperative MRI in determining the best approach for an individual patient.
比较经腹会阴联合直肠癌根治术(ELAPER)与传统经腹会阴联合切除术(APER)的短期肿瘤学和临床结局。
这是一项对前瞻性维护数据库的回顾性研究,纳入了2013年7月1日至2015年1月31日期间在塔塔纪念中心接受APER的所有直肠癌患者。评估的短期肿瘤学参数包括环周切缘受累情况(CRM)、肿瘤部位穿孔情况以及清扫淋巴结数量。围手术期结局包括失血量、住院时间、术后会阴伤口并发症及30天死亡率。采用χ²检验比较两组结果。
本研究纳入42例ELAPER病例和78例传统APER病例。与传统组相比,ELAPER组提肛肌受累率显著更高;除此之外,两组在所有方面均具有可比性。传统组有7例患者(8.9%)出现CRM受累,而ELAPER组有3例患者(7.14%)出现CRM受累。ELAPER组的中位住院时间显著更长。对影响CRM阳性的因素进行单因素分析未显示出任何显著性。
对于累及提肛肌的低位直肠癌,ELAPER应是首选术式。对于术前磁共振成像(MRI)显示未累及提肛肌的病例,目前证据不足以推荐ELAPER优于传统APER。这强调了术前MRI在为个体患者确定最佳手术方式中的重要性。