Hagemann J, Pietsch R, Kruse I, Flemming B, Weinmeister S, Schmidt I, Strangfeld D, Schürer M, Siewert H
Klinik für Innere Medizin Theodor Brugsch, Bereiches Medizin der Humboldt-Universität zu Berlin.
Z Urol Nephrol. 1989 Mar;82(3):143-50.
Unilateral nephrectomy was performed in 109 male Wistar rats, 35 animals served as controls. Determinations of glomerular filtration rate (GFR) using slope clearance of 99mTc-DTPA and of tubular function using an orally water-loading test were made. The tests were performed 2 and 5 days as well as 2, 4, 5 and 6 weeks after nephrectomy. In all examinations the GFR was more than 50% of the level of two-kidney control animals. Fractional maximum diuresis was increased in the first 2 examinations after nephrectomy from 8.9 +/- 2.1 to 15.4 +/- 4.2% of the GFR and fractional clearance of osmotically free water from 6.8 +/- 1.9 to 10.9 +/- 3.5%. In the fourth and sixth week the proximal tubular reabsorption was increased and the glomerulo-tubular balance had been recovered. However, the minimal urine osmolarity was increased to 107.8 +/- 17.7 mmol/l and the osmotic load of the nephrons remained elevated. Possible clinical implications of the results are discussed.
对109只雄性Wistar大鼠进行了单侧肾切除术，35只动物作为对照。使用99mTc-DTPA的斜率清除率测定肾小球滤过率（GFR），并通过口服水负荷试验测定肾小管功能。在肾切除术后2天、5天以及2周、4周、5周和6周进行测试。在所有检查中，GFR均超过双肾对照动物水平的50%。肾切除术后的前两次检查中，最大利尿分数从GFR的8.9±2.1%增加到15.4±4.2%，渗透自由水的分数清除率从6.8±1.9%增加到10.9±3.5%。在第四周和第六周，近端肾小管重吸收增加，肾小球-肾小管平衡得以恢复。然而，最小尿渗透压增加到107.8±17.7 mmol/l，肾单位的渗透负荷仍然升高。讨论了这些结果可能的临床意义。
