Schiffman P L, Belsh J M
Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08903-0019.
Am Rev Respir Dis. 1989 Jun;139(6):1418-23. doi: 10.1164/ajrccm/139.6.1418.
The effect of breathing through inspiratory flow resistive loads ranging between 4.5 and 27.0 cm H2O/L/s was assessed in eight patients with amyotrophic lateral sclerosis (ALS) and in eight control subjects. ALS patients developed respiratory muscle fatigue manifested by significant declines in negative inspiratory pressure (18.3%), vital capacity (7.2%), and peak inspiratory flow rate (5.5%). Control subjects did not fatigue with these resistances. In ALS patients, theophylline increased respiratory muscle strength after resistive breathing as manifested by an increase in negative inspiratory pressure (28.2%), vital capacity (10%), and peak inspiratory flow rate (11.8%). It is concluded that in patients with ALS, the already weakened respiratory muscles are easily fatigued. Furthermore, theophylline can strengthen loaded respiratory muscles in patients with ALS.
在8例肌萎缩侧索硬化症（ALS）患者和8名对照受试者中，评估了通过4.5至27.0厘米水柱/升/秒范围内的吸气气流阻力负荷进行呼吸的效果。ALS患者出现呼吸肌疲劳，表现为吸气负压显著下降（18.3%）、肺活量下降（7.2%）和吸气峰值流速下降（5.5%）。对照受试者在这些阻力下未出现疲劳。在ALS患者中，茶碱在阻力呼吸后增加了呼吸肌力量，表现为吸气负压增加（28.2%）、肺活量增加（10%）和吸气峰值流速增加（11.8%）。得出的结论是，在ALS患者中，本已虚弱的呼吸肌很容易疲劳。此外，茶碱可以增强ALS患者负荷状态下的呼吸肌力量。
