重组α干扰素眼部给药的安全性和耐受性。
Safety and tolerance of ocular administration of recombinant alpha interferon.
作者信息
Turner R B, Durcan F J, Albrecht J K, Crandall A S
机构信息
Department of Pediatrics, University of Utah School of Medicine, Salt Lake City 84132.
出版信息
Antimicrob Agents Chemother. 1989 Mar;33(3):396-7. doi: 10.1128/AAC.33.3.396.
Abstract
The safety, tolerance, and levels of drug in the nasal cavity produced by an ocular formulation of interferon were determined at four dosages in a placebo-controlled, double-masked trial. Interferon given by the ocular route was generally well tolerated, although a dose-related occurrence of subjective symptoms was detected.
摘要
在一项安慰剂对照、双盲试验中，以四种剂量测定了干扰素眼部制剂在鼻腔内产生的药物安全性、耐受性和水平。经眼部途径给予的干扰素一般耐受性良好，尽管检测到主观症状的发生与剂量相关。
相似文献
1
Safety and tolerance of ocular administration of recombinant alpha interferon.重组α干扰素眼部给药的安全性和耐受性。
Antimicrob Agents Chemother. 1989 Mar;33(3):396-7. doi: 10.1128/AAC.33.3.396.
2
Tolerance and efficacy of intranasal administration of recombinant beta serine interferon in healthy adults.健康成年人鼻内给予重组β-丝氨酸干扰素的耐受性和疗效。
J Infect Dis. 1988 Jul;158(1):166-75. doi: 10.1093/infdis/158.1.166.
3
Tolerance and nasal histopathologic effects of long-term, low-dose intranasal recombinant interferon alpha-2A (Roferon-A).长期低剂量鼻内注射重组干扰素α-2A（罗扰素）的耐受性及鼻组织病理学效应
Antiviral Res. 1987 Oct;8(3):139-49. doi: 10.1016/0166-3542(87)90067-2.
4
Randomized, double-masked comparison of olopatadine ophthalmic solution, mometasone furoate monohydrate nasal spray, and fexofenadine hydrochloride tablets using the conjunctival and nasal allergen challenge models.使用结膜和鼻腔过敏原激发模型对奥洛他定滴眼液、糠酸莫米松一水合物鼻喷雾剂和盐酸非索非那定片进行随机、双盲比较。
Clin Ther. 2003 Aug;25(8):2245-67. doi: 10.1016/s0149-2918(03)80217-5.
5
Efficacy and tolerance of intranasally applied recombinant leukocyte A interferon in normal volunteers.鼻腔内应用重组白细胞A干扰素在正常志愿者中的疗效和耐受性。
J Infect Dis. 1983 Sep;148(3):535-42. doi: 10.1093/infdis/148.3.535.
6
Intranasal interferon alpha 2 for prevention of rhinovirus infection and illness.鼻内注射干扰素α2预防鼻病毒感染和疾病。
J Infect Dis. 1983 Sep;148(3):543-50. doi: 10.1093/infdis/148.3.543.
7
Intranasally applied recombinant leukocyte A interferon in normal volunteers. II. Determination of minimal effective and tolerable dose.正常志愿者经鼻应用重组白细胞A干扰素。II. 最小有效剂量和可耐受剂量的测定。
J Infect Dis. 1984 Aug;150(2):181-8. doi: 10.1093/infdis/150.2.181.
8
Human tolerance and histopathologic effects of long-term administration of intranasal interferon-alpha 2.长期鼻内给予干扰素-α 2的人体耐受性和组织病理学效应。
J Infect Dis. 1983 Nov;148(5):914-21. doi: 10.1093/infdis/148.5.914.
9
Prophylactic efficacy and tolerance of low-dose intranasal interferon-alpha 2 in natural respiratory viral infections.低剂量鼻内注射干扰素-α 2在自然呼吸道病毒感染中的预防效果及耐受性
Antiviral Res. 1985 Apr;5(2):111-6. doi: 10.1016/0166-3542(85)90037-3.
10
The transmucosal absorption of recombinant human interferon-alpha B/D hybrid in the rat and rabbit.重组人干扰素α B/D 杂合体在大鼠和兔体内的经黏膜吸收情况
J Pharm Pharmacol. 1995 Sep;47(9):721-4. doi: 10.1111/j.2042-7158.1995.tb06730.x.
引用本文的文献
1
Clinical pharmacokinetics of interferons.干扰素的临床药代动力学
Clin Pharmacokinet. 1990 Nov;19(5):390-9. doi: 10.2165/00003088-199019050-00003.
本文引用的文献
1
Intranasally applied recombinant leukocyte A interferon in normal volunteers. II. Determination of minimal effective and tolerable dose.正常志愿者经鼻应用重组白细胞A干扰素。II. 最小有效剂量和可耐受剂量的测定。
J Infect Dis. 1984 Aug;150(2):181-8. doi: 10.1093/infdis/150.2.181.
2
Sites of virus recovery and antigen detection in epithelial cells during experimental rhinovirus infection.实验性鼻病毒感染期间上皮细胞中病毒恢复和抗原检测的部位。
Acta Otolaryngol Suppl. 1984;413:9-14. doi: 10.3109/00016488409128535.
3
Prophylactic efficacy and tolerance of low-dose intranasal interferon-alpha 2 in natural respiratory viral infections.低剂量鼻内注射干扰素-α 2在自然呼吸道病毒感染中的预防效果及耐受性
Antiviral Res. 1985 Apr;5(2):111-6. doi: 10.1016/0166-3542(85)90037-3.
4
Sites of rhinovirus recovery after point inoculation of the upper airway.上呼吸道点接种后鼻病毒的恢复部位。
JAMA. 1986 Oct 3;256(13):1763-7.
5
Prevention of experimental coronavirus colds with intranasal alpha-2b interferon.经鼻给予α-2b干扰素预防实验性冠状病毒感冒
J Infect Dis. 1986 Sep;154(3):443-7. doi: 10.1093/infdis/154.3.443.
6
Intranasal interferon-alpha 2b for seasonal prophylaxis of respiratory infection.鼻内注射干扰素α-2b用于季节性预防呼吸道感染。
J Infect Dis. 1986 Jul;154(1):128-33. doi: 10.1093/infdis/154.1.128.
7
Prevention of natural colds by contact prophylaxis with intranasal alpha 2-interferon.通过鼻内α2干扰素接触预防来预防自然感冒。
N Engl J Med. 1986 Jan 9;314(2):71-5. doi: 10.1056/NEJM198601093140202.
8
Prophylactic efficacy of intranasal alpha 2-interferon against rhinovirus infections in the family setting.鼻内注射α2干扰素在家庭环境中对鼻病毒感染的预防效果。
N Engl J Med. 1986 Jan 9;314(2):65-70. doi: 10.1056/NEJM198601093140201.
Zotero 插件