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一名类风湿关节炎患者经手术治疗的造口周围坏疽性脓皮病病例。

A case of surgically treated peristomal pyoderma gangrenosum in a patient with rheumatoid arthritis.

作者信息

Khajehnoori Masoomeh, O'Brien Tim

机构信息

Department of General Surgery, University Hospital, Barwon Health, Geelong, VIC, Australia,

Department of Medicine, University Hospital, Barwon Health, Geelong, VIC, Australia.

出版信息

J Surg Case Rep. 2016 Jun 14;2016(6):rjw103. doi: 10.1093/jscr/rjw103.

Abstract

Peristomal pyoderma gangrenosum (PPG) is a rare subtype of pyoderma gangrenosum that is difficult to diagnose and treat. It is characterized by the rapid progression of painful necrotic ulcer surrounding an area of abdominal stoma. It is almost exclusively associated with inflammatory bowel disease even after bowel surgery and is associated with significant morbidity. Diagnosis of pyoderma gangrenosum is based on exclusion of other disorders replicating some of its clinical features and histopathological evidence.This is a case report of a 56-year-old lady with rheumatoid arthritis who presented with rapidly progressing abdominal ulcer 8 months after a Hartmanns procedure for perforated diverticulitis. The ulcer had formed a large cavity causing faecal filling in the dependent defect. The other causes of ulcer were excluded with negative histopathology, negative polymerase chain reaction for Mycobacterium ulcerans and negative acid fast bacillus (AFB) test. She was diagnosed with PPG which is routinely treated medically due to risk of setting off a second focus of pyoderma if surgically intervened. However due to increased risk of faecal peritonitis, it was decided to proceed with surgical debridement. This article will discuss the case in more detail and briefly discuss diagnosis and treatment options for PPG.

摘要

造口周围坏疽性脓皮病(PPG)是坏疽性脓皮病的一种罕见亚型,诊断和治疗都很困难。其特征是围绕腹部造口区域的疼痛性坏死性溃疡迅速进展。即使在肠道手术后,它几乎仅与炎症性肠病相关,且会导致严重的发病率。坏疽性脓皮病的诊断基于排除其他具有一些其临床特征的疾病以及组织病理学证据。这是一例56岁类风湿关节炎女性的病例报告,她在因穿孔性憩室炎接受哈特曼手术8个月后出现迅速进展的腹部溃疡。溃疡形成了一个大腔隙,导致粪便填充在低垂的缺损处。通过组织病理学阴性、溃疡分枝杆菌聚合酶链反应阴性和抗酸杆菌(AFB)检测阴性排除了溃疡的其他病因。她被诊断为PPG,由于手术干预有引发坏疽性脓皮病第二个病灶的风险,通常采用药物治疗。然而,由于粪性腹膜炎风险增加,决定进行手术清创。本文将更详细地讨论该病例,并简要讨论PPG的诊断和治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/054b/4906534/239bc30ec830/rjw103f01.jpg

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