Chang Gung University, Graduate Institute of Electro-Optical Engineering, No. 259, Wenhua 1st Road, Kwei-shan District, Taoyuan 333, TaiwanbInstitute of Chemistry, Academic Sinica, No. 128, Section 2, Academia Road, Nankang District, Taipei 115, Taiwan.
Chang Gung University, Graduate Institute of Electro-Optical Engineering, No. 259, Wenhua 1st Road, Kwei-shan District, Taoyuan 333, Taiwan.
J Biomed Opt. 2016 Jun 1;21(6):60504. doi: 10.1117/1.JBO.21.6.060504.
The surface effect close to the boundary of a small light-scattering object in a highly scattering medium is experimentally demonstrated. This is the first attempt to measure the surface effect of a small spherical scattering object in 1% intralipid solution by use of developed diffuse photon-pairs density wave (DPPDW) in terms of the amplitude and phase detection. Theoretically, the surface effect of a small scattering object in turbid media is localized close to the boundary according to the perturbation theory, concerning an inhomogeneous distribution of the diffusion coefficient in the frequency-domain diffusion equation. Hence, an improvement of the spatial resolution of the image via an inverse algorithm, which relates to detection sensitivity of localization to the boundary of the image object in a multiple scattering medium, is anticipated. In this study, we demonstrate that DPPDW is able to sense the surface effect of a 2-mm spherical scattering object in 1% intralipid solution, with high sensitivity. Subsequently, an improvement of spatial resolution of imaging in turbid media by using DPPDW in comparison with conventional diffuse photon density wave (DPDW) using inverse algorithm is discussed.
在高度散射介质中靠近小光散射物体边界的表面效应被实验证明。这是首次尝试通过使用开发的漫射光子对密度波（DPPDW）在幅度和相位检测方面，测量 1%脂肪乳剂溶液中小球形散射物体的表面效应。根据频域扩散方程中扩散系数的非均匀分布的微扰理论，理论上，小散射物体在浑浊介质中的表面效应被局限在靠近边界处。因此，通过与多散射介质中图像对象边界的定位检测灵敏度相关的反演算法，可以提高图像的空间分辨率。在这项研究中，我们证明了 DPPDW 能够以高灵敏度感应 1%脂肪乳剂溶液中 2mm 球形散射物体的表面效应。随后，通过使用反演算法比较使用 DPPDW 和常规漫射光子密度波（DPDW），讨论了在浑浊介质中使用 DPPDW 提高成像空间分辨率的问题。
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