抗糖尿病干预对恶性生长和转移的相反作用。
Opposing Effects of Antidiabetic Interventions on Malignant Growth and Metastasis.
机构信息
Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Division of Endocrinology, University Hospital Leipzig, 04103 Leipzig, Germany.
出版信息
Cell Metab. 2016 Jun 14;23(6):959-960. doi: 10.1016/j.cmet.2016.05.017.
Type 2 diabetes is associated with increased risk of malignancies, whereas antidiabetic interventions like physical exercise or metformin reduce cancer incidence. A recent publication shows that one diabetes treatment approach, namely incretin-related DPP4 inhibitors, increases metastatic capacity by activating the antioxidant transcription factor NRF2 to decrease reactive oxygen species (ROS) levels.
2 型糖尿病与恶性肿瘤风险增加有关，而像体育锻炼或二甲双胍这样的抗糖尿病干预措施则可以降低癌症发病率。最近的一篇出版物表明，一种糖尿病治疗方法，即肠促胰岛素相关的 DPP4 抑制剂，通过激活抗氧化转录因子 NRF2 来增加转移能力，从而降低活性氧（ROS）水平。
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