胶质细胞在瘦素作用和能量平衡中的新角色

A New Role for Glia in Leptin Action and Energy Balance.

机构信息

Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA; Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48105, USA.

Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA; Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48105, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48105, USA.

出版信息

Cell Metab. 2016 Jun 14;23(6):969-970. doi: 10.1016/j.cmet.2016.05.020.

DOI:10.1016/j.cmet.2016.05.020

PMID:27304498

Abstract

Chemo- or radiotherapy against dividing cells in the brain can promote obesity. Djogo et al. (2016) suggest that the loss of NG2 glia and diminished leptin action in the median eminence underlie this response, likely due to the loss of dendrites originating in the adjacent arcuate nucleus.

摘要

化疗或放疗对大脑中分裂细胞的作用可能会导致肥胖。Djogo 等人（2016 年）提出，这一反应的基础是正中隆起处 NG2 神经胶质的丧失和瘦素作用减弱，这可能是由于起源于相邻弓状核的树突丢失所致。