Mahler Ilanit, Ben Gal Tuvia, Kashtan Hanoch, Keidar Andrei
Harefuah. 2016 Mar;155(3):155-7, 196.
Morbid obesity affects the function of the transplanted heart either directly, by damaging many elements that affect cardiac function or indirectly, by the initial appearance or worsening of co-morbidities that affect the heart. Bariatric surgery is the most effective treatment for a significant and sustained decrease in weight and it leads to the disappearance of co-morbidities such as diabetes, hypertension and dyslipidemia in high rates. These diseases can damage the blood vessels of the graft and impair its function. We report a case study of a 47-year-old morbidly obese male (BMI 36 kg/m2] who underwent heart transplantation three years previously, developed gradual weight gain and symptoms of aggravating heart failure. Coronary artery disease in the implanted heart was diagnosed. Clinically, he started suffering from shortness of breath and chest pain during minimal effort. In addition, he also suffered from high blood pressure and kidney failure. Laparoscopic sleeve gastrectomy was successfully performed and he was discharged four days later. On follow-up the patient has lost 35 kg. His present weight is 74 kg (BMI 25.7). All symptoms of heart failure improved and oral medications for hypertension and heart failure were withdrawn. Our conclusion is that it is justified to consider bariatric surgery in heart transplant recipients suffering from morbid obesity, as long as the long-term benefit outweighs the surgical risk. The decision to perform bariatric surgery should be made by a multidisciplinary team and the operation should take place at a center with extensive experience in bariatric surgery.
病态肥胖可直接通过损害影响心脏功能的许多因素,或间接通过影响心脏的合并症初发或恶化来影响移植心脏的功能。减肥手术是显著且持续减轻体重的最有效治疗方法,它能使糖尿病、高血压和血脂异常等高发病率的合并症消失。这些疾病会损害移植心脏的血管并损害其功能。我们报告一例病例研究,一名47岁病态肥胖男性(BMI 36 kg/m²),三年前接受心脏移植,体重逐渐增加且出现心力衰竭加重症状。诊断出植入心脏患有冠状动脉疾病。临床上,他在轻微活动时开始出现呼吸急促和胸痛。此外,他还患有高血压和肾衰竭。成功实施了腹腔镜袖状胃切除术,四天后出院。随访时患者体重减轻了35 kg。他目前体重74 kg(BMI 25.7)。心力衰竭的所有症状均有改善,高血压和心力衰竭的口服药物停用。我们的结论是,对于患有病态肥胖的心脏移植受者,只要长期获益大于手术风险,考虑进行减肥手术是合理的。减肥手术的决定应由多学科团队做出,手术应在具有丰富减肥手术经验的中心进行。