Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1.
Leslie Dan School of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, Canada M5S 3M2.
Nat Commun. 2016 Jun 16;7:11937. doi: 10.1038/ncomms11937.
All organisms possess innate behavioural and physiological programmes that ensure survival. In order to have maximum adaptive benefit, these programmes must be sufficiently flexible to account for changes in the environment. Here we show that hypothalamic CRH neurons orchestrate an environmentally flexible repertoire of behaviours that emerge after acute stress in mice. Optical silencing of CRH neurons disrupts the organization of individual behaviours after acute stress. These behavioural patterns shift according to the environment after stress, but this environmental sensitivity is blunted by activation of PVN CRH neurons. These findings provide evidence that PVN CRH cells are part of a previously unexplored circuit that matches precise behavioural patterns to environmental context following stress. Overactivity in this network in the absence of stress may contribute to environmental ambivalence, resulting in context-inappropriate behavioural strategies.
所有生物体都拥有确保生存的先天行为和生理程序。为了获得最大的适应效益，这些程序必须具有足够的灵活性，以适应环境的变化。在这里，我们表明，下丘脑 CRH 神经元协调了一组环境灵活的行为，这些行为在小鼠急性应激后出现。CRH 神经元的光沉默会破坏急性应激后个体行为的组织。这些行为模式会根据应激后的环境而变化，但这种环境敏感性会被 PVN CRH 神经元的激活所削弱。这些发现为 PVN CRH 细胞是一个以前未被探索的回路的一部分提供了证据，该回路在应激后将精确的行为模式与环境背景相匹配。在没有应激的情况下，该网络的过度活跃可能导致环境矛盾，从而导致行为策略不当。
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