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随时间推移对感染艾滋病毒风险的态度与理解:一项针对英国男同性恋者的基于互联网的前瞻性队列研究(AURAH2研究)的设计与方法

Attitudes to and Understanding of Risk of Acquisition of HIV Over Time: Design and Methods for an Internet-based Prospective Cohort Study Among UK Men Who Have Sex With Men (the AURAH2 Study).

作者信息

Sewell Janey, Speakman Andrew, Phillips Andrew N, Cambiano Valentina, Lampe Fiona C, Gilson Richard, Asboe David, Nwokolo Nneka, Clarke Amanda, Ogilvy Ali, Collins Simon, Rodger Alison J

机构信息

Department of Infection and Population Health, UCL, London, United Kingdom.

出版信息

JMIR Res Protoc. 2016 Jun 15;5(2):e128. doi: 10.2196/resprot.5582.

Abstract

BACKGROUND

The annual number of new human immunodeficiency virus (HIV) infections among men who have sex with men (MSM) has risen in the United Kingdom and, of those who are HIV positive, the proportion undiagnosed is high.

OBJECTIVE

The prospective AURAH2 study aims to assess factors associated with HIV acquisition among MSM in the United Kingdom and to investigate changes over time within individuals in sexual behavior and HIV-testing practices.

METHODS

AURAH2 is a prospective study among MSM without diagnosed HIV, aiming to recruit up to 1000 sexually active MSM attending sexual health clinics in London and Brighton in the United Kingdom. Participants complete an initial paper-based questionnaire, followed by online follow-up questionnaires every 4 months collecting sociodemographic, health and behavioral data, including sexual behavior, recreational and other drug use, HIV testing practices, and pre-exposure prophylaxis use, over a planned 3-year period.

RESULTS

The study is ongoing.

CONCLUSIONS

The results from AURAH2 study will provide important insight into established and emerging risk behaviors that may be associated with acquisition of HIV in MSM in the United Kingdom, changes over time within individuals in sexual behavior, and information on HIV testing practices. These data will be crucial to inform future HIV prevention strategies.

摘要

背景

在英国,男男性行为者(MSM)中每年新感染人类免疫缺陷病毒(HIV)的人数有所上升,且在HIV阳性者中,未被诊断出的比例很高。

目的

前瞻性AURAH2研究旨在评估英国男男性行为者中与HIV感染相关的因素,并调查个体性行为和HIV检测行为随时间的变化。

方法

AURAH2是一项针对未诊断出HIV的男男性行为者的前瞻性研究,旨在招募多达1000名在英国伦敦和布莱顿的性健康诊所就诊的性活跃男男性行为者。参与者首先完成一份纸质问卷,随后在计划的3年时间里,每4个月通过在线随访问卷收集社会人口统计学、健康和行为数据,包括性行为、娱乐及其他药物使用情况、HIV检测行为以及暴露前预防用药情况。

结果

研究正在进行中。

结论

AURAH2研究的结果将为英国男男性行为者中可能与HIV感染相关的既定和新出现的风险行为、个体性行为随时间的变化以及HIV检测行为信息提供重要见解。这些数据对于为未来的HIV预防策略提供依据至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/913d/4927873/99a4997577b0/resprot_v5i2e128_fig1.jpg

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