Hrustanovic Gorjan, Bivona Trever G
Division of Hematology and Medical Oncology, University of California San Francisco, San Francisco, CA, USA; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.
Mol Cell Oncol. 2015 Oct 29;3(2):e1091061. doi: 10.1080/23723556.2015.1091061. eCollection 2016 Mar.
ALK (anaplastic lymphoma kinase) inhibitors are approved in for ALK gene rearrangement positive (ALK+) lung cancer, but resistance remains a challenge. We discovered that RAS-RAF-MEK-ERK signaling controls the ALK inhibitor response in ALK+ lung cancer and is critical for ALK inhibitor resistance. Upfront ALK-MEK inhibitor polytherapy may enhance response and forestall resistance.
间变性淋巴瘤激酶(ALK)抑制剂已被批准用于治疗ALK基因重排阳性(ALK+)的肺癌,但耐药性仍然是一个挑战。我们发现,RAS-RAF-MEK-ERK信号通路控制着ALK+肺癌对ALK抑制剂的反应,并且对ALK抑制剂耐药性至关重要。一线使用ALK-MEK抑制剂联合治疗可能会增强疗效并预防耐药。