死产儿主动脉根部的形态计量学评估。

Morphometric evaluation of the aortic root in stillborns.

作者信息

da Fonseca Ferraz Mara Lúcia, Franco Calline Alves, Juliano Gabriela Ribeiro, Juliano Guilherme Ribeiro, de Almeida João Antônio, Soares Maria Helena, Oliveira Lívia Ferreira, Ramalho Luciana Santos, Cavellani Camila Lourencini, Espindula Ana Paula, Corrêa Rosana Rosa Miranda, de Oliveira Flávia Aparecida, Dos Reis Marlene Antônia, de Paula Antunes Teixeira Vicente

机构信息

General Pathology Sector, Biological and Natural Sciences Institute (ICBN), Triângulo Mineiro Federal University (UFTM), Uberaba, MG, Brazil.

Medical School, Atenas University, Paracatu, MG, Brazil.

出版信息

Pathol Res Pract. 2016 Aug;212(8):686-9. doi: 10.1016/j.prp.2016.03.012. Epub 2016 Apr 1.

DOI:10.1016/j.prp.2016.03.012

PMID:27317554

Abstract

OBJECTIVE

To describe the dimensions and amount of collagen in the aortic root of autopsied fetuses at different gestational ages.

MATERIAL AND METHODS

40 samples of aortic roots were selected from autopsied fetuses with gestational ages ranging between 20 and 40 weeks. The thickness and the area of the aortic wall were analyzed on slides stained with Hematoxylin and Eosin, and the collagen was quantified on slides stained with Picrosirius, by using an image analyzing system.

RESULTS

A positive correlation was observed between the thickness of the media layer of the aortic wall and the gestational age. There was a positive and significant correlation between the percentage of collagen in the aortic wall with gestational age and fetal weight. The correlation between gestational age and the area of the aortic root circumference was positive and significant. And the correlation between the aortic diameter and the gestational age as well as fetal length was positive and significant.

CONCLUSION

The thickness of the media layer, the amount of collagen in the aortic wall, the area of the aortic root circumference and the aortic diameter rose with the increase of the gestational age. Thus, the morphological analysis of the aortic root may help as a parameter during the follow-up of inter-uterine growth and fetal development.

摘要