Dravecká Ingrid
Vnitr Lek. 2016 Spring;62(5):392-7.
Polycystic ovary syndrome (PCOS) is a heterogeneous and complex endocrine disease which among the female population belongs to the most widespread endocrinopathies and it is the most frequent cause of hyperthyroidism, anticoagulation and infertility. Insulin resistance is one of the important diabetology factors impacting hyperglycaemia in a majority of women with PCOS (60-80 %). Clinical expressions of PCOS include reproduction disorders, metabolic characteristics and psychological implications. Reproduction disorders include hyperthyroidism, menstruation cycle disorders, infertility and pregnancy complications as well as early abortions, gestational diabetes and pregnancy induced hypertension. Long-term metabolic risks of PCOS include type 2 diabetes mellitus, dyslipidemia, arterial hypertension and endothelial dysfunction. The available data confirms higher incidence of cardiovascular diseases in women with PCOS. In particular among obese women PCOS is more frequently associated with non-alcoholic hepatic steatosis, sleep apnoea syndrome and endometrial cancer. The literature includes some controversial data about the relationship between PCOS and autoimmunity. Women with PCOS are more prone to suffer from insufficient confidence with higher incidence of anxiety, depression, bipolar disorder and eating disorders.
autoimmunity - diabetes mellitus - pregnancy - insulin resistance - metabolic syndrome - menstrual disorders - polycystic ovary syndrome.
多囊卵巢综合征（PCOS）是一种异质性且复杂的内分泌疾病，在女性群体中属于最常见的内分泌病，也是甲状腺功能亢进、抗凝和不孕的最常见原因。胰岛素抵抗是影响大多数PCOS女性（60 - 80%）血糖升高的重要糖尿病学因素之一。PCOS的临床表现包括生殖障碍、代谢特征和心理影响。生殖障碍包括甲状腺功能亢进、月经周期紊乱、不孕和妊娠并发症以及早期流产、妊娠期糖尿病和妊娠高血压。PCOS的长期代谢风险包括2型糖尿病、血脂异常、动脉高血压和内皮功能障碍。现有数据证实PCOS女性患心血管疾病的发生率更高。特别是在肥胖女性中，PCOS更常与非酒精性肝脂肪变性、睡眠呼吸暂停综合征和子宫内膜癌相关。关于PCOS与自身免疫之间的关系，文献中有一些有争议的数据。PCOS女性更容易缺乏自信，焦虑、抑郁、双相情感障碍和饮食失调的发生率更高。
自身免疫 - 糖尿病 - 妊娠 - 胰岛素抵抗 - 代谢综合征 - 月经紊乱 - 多囊卵巢综合征
