正电子发射断层显像在泌尿生殖系统恶性肿瘤个体化治疗中的应用

PET Imaging Toward Individualized Management of Urologic and Gynecologic Malignancies.

作者信息

Sonni Ida, Iagaru Andrei

机构信息

Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA.

出版信息

PET Clin. 2016 Jul;11(3):261-72. doi: 10.1016/j.cpet.2016.02.007. Epub 2016 Mar 17.

DOI:10.1016/j.cpet.2016.02.007

PMID:27321030

Abstract

Advances in the understanding of cellular and molecular basis of tumor progression have spurred interest in the development of new targeted agents that are changing the therapeutic management of patients with cancer. In parallel to progression in the therapeutic area, new PET radiopharmaceuticals are being developed to guide the use of such targeted therapies. This article aims to give an overview on the role of PET imaging in the individualized management of patients affected by urologic and gynecologic malignancies, focusing on the most promising targets for therapies and for molecular imaging using PET.

摘要

对肿瘤进展的细胞和分子基础认识的进步激发了人们对开发新型靶向药物的兴趣，这些药物正在改变癌症患者的治疗管理。与治疗领域的进展同步，新型正电子发射断层显像（PET）放射性药物正在研发中，以指导此类靶向治疗的应用。本文旨在概述PET成像在泌尿生殖系统恶性肿瘤患者个体化管理中的作用，重点关注最有前景的治疗靶点以及PET分子成像靶点。