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评估接受常规胰岛素或胰岛素类似物治疗的糖尿病患者的生活质量。

Evaluation of the quality of life of patients with diabetes mellitus treated with conventional or analogue insulins.

作者信息

Machado-Alba Jorge Enrique, Medina-Morales Diego Alejandro, Echeverri-Cataño Luis Felipe

机构信息

Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A., Pereira, Colombia.

出版信息

Diabetes Res Clin Pract. 2016 Jun;116:237-43. doi: 10.1016/j.diabres.2016.04.039. Epub 2016 Apr 27.

Abstract

AIMS

The results of two scales that measure quality of life of patients with diabetes mellitus treated with conventional or analogue insulin were evaluated and compared.

METHODS

Descriptive, observational, cross-sectional study, conducted in the cities of Pereira and Manizales, Colombia, in a care facility between 1 August 2013 and 30 March 2014. A total of 238 patients diagnosed with diabetes mellitus type 1 or type 2 who had been undergoing treatment with conventional or analogue insulin for at least 6months. Comparison of the results of the Diabetes 39 (specific) and European Quality of Life-5 Dimensions (EQ-5D) (generic) tools it was performed. Comparisons between the results of the two instruments were performed. Tests for parametric and non-parametric distribution (Pearson's correlation coefficient, Mann-Whitney U test, Student's t-test and Wilcoxon test) were used.

RESULTS

The mean age was 57.7±16.6years. Conventional insulin was prescribed to 69.6% of patients, and analogue insulin was prescribed to 30.4% of patients. Diabetes-39 (D-39) showed 24.7% of subjects with a high quality of life. No statistically significant differences were found when comparing patients prescribed conventional or analogue insulin (p=0.35; 95% confidence interval [CI]: 0.375-1.419). In the EQ-5D survey, 45.7% claimed to have a high quality of life, without statistically significant differences between groups (p=0.56; 95%CI: 0.676-2.047).

CONCLUSIONS

No differences between patients receiving conventional insulin versus analogue insulin were detected in terms of quality of life. The group aged over 60years requires special attention to improve their quality of life, and programs should focus on those individuals.

摘要

目的

评估并比较两种用于测量接受常规胰岛素或胰岛素类似物治疗的糖尿病患者生活质量的量表的结果。

方法

于2013年8月1日至2014年3月30日在哥伦比亚佩雷拉市和马尼萨莱斯市的一家护理机构开展描述性、观察性、横断面研究。共有238例诊断为1型或2型糖尿病且接受常规胰岛素或胰岛素类似物治疗至少6个月的患者。对糖尿病39项(特异性)和欧洲生活质量五维度(EQ - 5D)(通用性)工具的结果进行比较。对两种工具的结果进行了比较。使用了参数和非参数分布检验(皮尔逊相关系数、曼 - 惠特尼U检验、学生t检验和威尔科克森检验)。

结果

平均年龄为57.7±16.6岁。69.6%的患者使用常规胰岛素,30.4%的患者使用胰岛素类似物。糖尿病39项量表(D - 39)显示24.7%的受试者生活质量高。比较使用常规胰岛素或胰岛素类似物的患者时未发现统计学显著差异(p = 0.35;95%置信区间[CI]:0.375 - 1.419)。在EQ - 5D调查中。45.7%的人声称生活质量高,组间无统计学显著差异(p = 0.56;95%CI:0.676 - 2.047)。

结论

在生活质量方面,未检测到接受常规胰岛素与胰岛素类似物治疗的患者之间存在差异。60岁以上的人群需要特别关注以提高其生活质量,项目应关注这些个体。

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