Lifschitz C H, Shulman R J, Langston C, Gopalakrishna G S
United States Department of Agriculture, Children's Nutrition Research Center, Houston, TX 77030.
J Pediatr Gastroenterol Nutr. 1989 Jan;8(1):47-50. doi: 10.1097/00005176-198901000-00010.
The determination of serum levels of D-xylose and the urinary excretion of an orally administered mixture of low-molecular-weight polyethylene glycol were compared to assess their sensitivity to predict small-bowel mucosal damage. Eighteen infants with severe diarrhea and villus atrophy were observed. Results of the D-xylose and polyethylene glycol tests were compared with the villus-to-crypt ratios that were determined from biopsy specimens. The D-xylose test predicted accurately 12 (67%) of the 18 small-bowel biopsy results, while the polyethylene glycol test predicted 14 (78%). However, the McNemar test indicated that the two tests did not differ significantly in their ability to predict an abnormal small-bowel biopsy. We conclude that neither the D-xylose nor the polyethylene glycol test is a reliable indicator of small intestinal mucosal damage in infants with chronic diarrhea.
比较血清D-木糖水平测定和口服低分子量聚乙二醇混合物的尿排泄情况，以评估它们预测小肠黏膜损伤的敏感性。观察了18例患有严重腹泻和绒毛萎缩的婴儿。将D-木糖和聚乙二醇试验的结果与从活检标本中确定的绒毛与隐窝比值进行比较。D-木糖试验准确预测了18例小肠活检结果中的12例（67%），而聚乙二醇试验预测了14例（78%）。然而，McNemar检验表明，这两种试验在预测异常小肠活检的能力上没有显著差异。我们得出结论，D-木糖试验和聚乙二醇试验都不是慢性腹泻婴儿小肠黏膜损伤的可靠指标。
