普拉德-威利综合征和非综合征性肥胖中的喂养、进食及行为障碍
Feeding, eating and behavioral disturbances in Prader-Willi syndrome and non-syndromal obesity.
作者信息
Sonnengrün Lilli, Schober Celestina, Vogel Mandy, Hiemisch Andreas, Döhnert Mirko, Hilbert Anja, Kiess Wieland
出版信息
J Pediatr Endocrinol Metab. 2016 Aug 1;29(8):923-32. doi: 10.1515/jpem-2016-0085.
BACKGROUND
Although most individuals with Prader-Willi syndrome (PWS) are obese, little is known about the impact of obesity-related psychosocial factors in PWS. In the present study we compared feeding, eating, and behavioral disturbances in children and adolescents with PWS, peers with non-syndromal obesity, and normal weight controls.
METHODS
Twelve persons with PWS, aged 7-22 years, age- and gender-matched obese and normal weight individuals were analyzed regarding parental feeding practices, eating disturbances, and behavioral problems via standardized questionnaires.
RESULTS
Parents of individuals with PWS reported significantly more restrictive feeding and monitoring than did parents of obese or normal weight children without PWS (p<0.05). Social problems were more common in the obese and the PWS group than in the normal-weight group (p<0.05). Behavioral problems were significantly correlated with parental restrictive feeding practices.
CONCLUSIONS
Our data show that children and adolescents with PWS are affected by psychosocial problems, and that restrictive feeding practices might be associated with more severe behavioral problems. Further studies in larger samples will be necessary to replicate these results and possibly provide new therapeutic approaches for the management of PWS.
背景
尽管大多数普拉德-威利综合征（PWS）患者肥胖，但关于肥胖相关心理社会因素对PWS的影响知之甚少。在本研究中，我们比较了患有PWS的儿童和青少年、非综合征性肥胖同龄人以及正常体重对照组在进食、饮食和行为障碍方面的情况。
方法
通过标准化问卷，对12名年龄在7至22岁的PWS患者、年龄和性别匹配的肥胖及正常体重个体的父母喂养方式、饮食障碍和行为问题进行了分析。
结果
与没有PWS的肥胖或正常体重儿童的父母相比，PWS患者的父母报告的限制性喂养和监控显著更多（p<0.05）。社会问题在肥胖组和PWS组比正常体重组更常见（p<0.05）。行为问题与父母的限制性喂养方式显著相关。
结论
我们的数据表明，患有PWS的儿童和青少年受到心理社会问题的影响，而且限制性喂养方式可能与更严重的行为问题有关。需要在更大样本中进行进一步研究以复制这些结果，并可能为PWS的管理提供新的治疗方法。
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