Kaufman H E, Katz J I
Trans Ophthalmol Soc U K (1962). 1977 Jul;97(2):265-7.
Methacrylate surfaces adhere to corneal endothelial cell membranes and appear to tear off the cell membranes as they separate. This adhesion appears to cause much of the massive cell damage seen at the time of intraocular lens insertion even in the hands of several groups of very experienced implant surgeons. The damage appears correlated with the incidence of endothelial touch, and may be avoidable both by avoiding contact, even for a brief period, between the endothelium and the intraocular lens during insertion, and by increasing the safety of such lenses through a hydrophilic protective coating which would give a surface similar to human lens epithelium or soft contact lens material which does not damage the endothelium. It is possible that similar damage also plays a role in causing abdominal adhesions through contact with rubber gloves, as well as venous thromboses and urethral strictures.
甲基丙烯酸酯表面会附着在角膜内皮细胞膜上，并且在分离时似乎会撕下细胞膜。即使在几组经验非常丰富的植入外科医生手中，这种附着力似乎也是导致人工晶状体植入时出现大量细胞损伤的主要原因。这种损伤似乎与内皮接触的发生率相关，并且通过在植入过程中避免内皮与人工晶状体之间即使是短时间的接触，以及通过亲水性保护涂层提高此类晶状体的安全性（该涂层会赋予类似于人晶状体上皮或不会损伤内皮的软性隐形眼镜材料的表面），这种损伤可能是可以避免的。类似的损伤也可能在通过与橡胶手套接触导致腹部粘连以及静脉血栓形成和尿道狭窄方面起作用。
