中国广西新生儿筛查发现的先天性甲状腺功能减退症患者的发病率及相关因素
Incidence and Interrelated Factors in Patients With Congenital Hypothyroidism as Detected by Newborn Screening in Guangxi, China.
作者信息
Fan Xin, Chen Shaoke, Qian Jiale, Sooranna Suren, Luo Jingi, Li Chuan, Tang Qin, Lin Caijuan
机构信息
Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China.
Imperial College London, London, UK; Chelsea and Westminster Hospital, London, UK.
出版信息
Glob Pediatr Health. 2015 Jan 19;2:2333794X14567193. doi: 10.1177/2333794X14567193. eCollection 2015.
Background. A newborn screening program (NSP) for congenital hypothyroidism (CH) was carried out in Guangxi in order to understand the incidence of CH and the factors interrelated to major types of CH in this region of China. Methods. During 2009 to 2013, data from 930 612 newborns attending NSP in Guangxi were collected. Patients were classified with either permanent CH (PCH) or transient CH (TCH) after 2 years of progressive study. Results. A total of 1210 patients were confirmed with CH with an incidence of 1/769, including 68 PCH and 126 TCH cases with incidences of 1/6673 and 1/3385, respectively. The frequency of thyroid stimulating hormone values greater than 5 mIU/L was 7.2%, which, based on WHO guidelines, suggests that the population was mildly iodine deficient. Conclusions. The incidence of CH was high in Guangxi. Approximately two thirds of CH patients were TCH, which may be due to a deficiency in iodine within the population.
背景。为了解中国广西地区先天性甲状腺功能减退症（CH）的发病率以及与主要CH类型相关的因素，开展了先天性甲状腺功能减退症新生儿筛查项目（NSP）。方法。收集2009年至2013年期间广西参加NSP的930612名新生儿的数据。经过2年的随访研究，将患者分为永久性CH（PCH）或暂时性CH（TCH）。结果。共有1210例患者确诊为CH，发病率为1/769，其中包括68例PCH和126例TCH病例，发病率分别为1/6673和1/3385。促甲状腺激素值大于5 mIU/L的频率为7.2%，根据世界卫生组织的指南，这表明该人群存在轻度碘缺乏。结论。广西CH的发病率较高。大约三分之二的CH患者为TCH，这可能是由于人群中碘缺乏所致。
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