Sharifi Alireza, Charjouei Moghadam Mohammad
Department of Mechanical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran ; Research Center for Biomedical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran.
Bioimpacts. 2016;6(1):41-7. doi: 10.15171/bi.2016.06. Epub 2016 Mar 28.
Buerger's disease is an occlusive arterial disease that occurs mainly in medium and small vessels. This disease is associated with Tobacco usage. The existence of corkscrew collateral is one of the established characteristics of the Buerger's disease.
In this study, the computational fluid dynamics (CFD) simulation of blood flow within the corkscrew artery of the Buerger's disease is conducted. The geometry of the artery is constructed based on the actual corkscrew artery of a patient diagnosed with the Buerger's disease. The blood properties are the same as the actual blood properties of the patient. The blood flow rate is taken from the available experimental data in the literature.
The local velocity patterns, pressure and kinematic viscosity distributions in different segments of the corkscrew collateral artery was demonstrated and discussed for the first time for this kind of artery. The effects of non-Newtonian consideration for the blood viscosity behavior were investigated in different segments of the artery. Moreover, the variations of the blood flow patterns along the artery were investigated in details for each segment.
It was found that the flow patterns were affected by the complex geometry of this artery in such a way that it could lead to the presence of sites that were prone to the accumulation of the flowing particles in blood like nicotine. Furthermore, due to the existence of many successive bends in this artery, the variations of kinematic viscosity along this artery were significant, therefore the non-Newtonian behavior of the blood viscosity must be considered.
血栓闭塞性脉管炎是一种主要发生在中小血管的闭塞性动脉疾病。这种疾病与吸烟有关。螺旋状侧支循环的存在是血栓闭塞性脉管炎已确定的特征之一。
在本研究中，对血栓闭塞性脉管炎螺旋动脉内的血流进行了计算流体动力学（CFD）模拟。动脉的几何形状是基于一名被诊断为血栓闭塞性脉管炎患者的实际螺旋动脉构建的。血液特性与患者的实际血液特性相同。血流速率取自文献中可用的实验数据。
首次展示并讨论了这种动脉螺旋状侧支动脉不同节段的局部速度模式、压力和运动粘度分布。在动脉的不同节段研究了血液粘度行为的非牛顿特性的影响。此外，详细研究了每个节段沿动脉的血流模式变化。
发现血流模式受该动脉复杂几何形状的影响，以至于可能导致血液中像尼古丁这样的流动颗粒易于积聚的部位出现。此外，由于该动脉存在许多连续的弯曲，沿该动脉的运动粘度变化显著，因此必须考虑血液粘度的非牛顿行为。
