伊朗人群中XRCC7基因G6721T多态性的患病率
Prevalence of G6721T polymorphism of XRCC7 in an Iranian population.
作者信息
Saadat Mostafa, Saadat Iraj
机构信息
Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran Institute of Biotechnology, Shiraz University, Shiraz, Iran.
出版信息
EXCLI J. 2012 Mar 15;11:93-7. eCollection 2012.
Genetic polymorphism G6721T (rs.7003908) in gene encoding DNA-dependent protein kinase (DNA-PKcs, encoded by the XRCC7 gene) has been defined. In order to get more insight into the genetic structure of Iranian population the present study was carried out on Iranian Persian population living in Shiraz (Fars province, southwest Iran). The total study subjects consisted of 935 (195 males, 740 females) unrelated healthy individuals. Genotypes of XRCC7 G6721T were detected by PCR-RFLP based method. There was no significant difference between males and females for the XRCC7 polymorphism (χ(2)=1.275, df=2, P=0.529). Prevalence of the G allele was 0.473 (95 % CI: 0.441-0.505) in our sample. The study population was at Hardy-Weinberg equilibrium for the XRCC7 polymorphism (χ(2)=0.980, df=1, P=0.323). The allelic frequency of the G allele showed high frequency in Iranian population compared to other populations.
编码DNA依赖性蛋白激酶（DNA-PKcs，由XRCC7基因编码）的基因中的遗传多态性G6721T（rs.7003908）已被确定。为了更深入了解伊朗人群的遗传结构，本研究对居住在设拉子（伊朗西南部法尔斯省）的伊朗波斯人群进行了调查。研究对象共计935名（195名男性，740名女性）无亲缘关系的健康个体。采用基于PCR-RFLP的方法检测XRCC7 G6721T的基因型。XRCC7基因多态性在男性和女性之间无显著差异（χ(2)=1.275，自由度=2，P=0.529）。在我们的样本中，G等位基因的频率为0.473（95%置信区间：0.441-0.505）。研究人群的XRCC7基因多态性处于哈迪-温伯格平衡状态（χ(2)=0.980，自由度=1，P=0.323）。与其他人群相比，G等位基因在伊朗人群中的等位基因频率较高。
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