伴有真性红细胞增多症的11三体骨髓增生异常综合征

Myelodysplastic syndrome with trisomy 11 associated with polycythemia vera.

作者信息

Ohyashiki K, Nagasu M, Hojo H, Iwabuchi A, Ohyashiki J H, Toyama K

机构信息

First Department of Internal Medicine, Tokyo Medical College, Japan.

出版信息

Am J Hematol. 1989 Jun;31(2):122-5. doi: 10.1002/ajh.2830310209.

DOI:10.1002/ajh.2830310209

PMID:2735317

Abstract

A 52-year-old male with myelodysplastic syndrome (MDS) who had a prior history of polycythemia vera is reported. Chromosome analysis revealed that the bone marrow and blood cells at the MDS phase contained trisomy of chromosome 11 as the sole cytogenetic change. Trisomy 11 is rarely found in hematologic neoplasia, and all of the reported cases with trisomy 11 were diagnosed as having nonlymphocytic neoplasia. In this report, a correlation between the chromosome change and leukemia/MDS developed in polycythemia vera is discussed.

摘要

报告了一名52岁患有骨髓增生异常综合征（MDS）的男性，其既往有真性红细胞增多症病史。染色体分析显示，处于MDS阶段的骨髓和血细胞中，11号染色体三体是唯一的细胞遗传学改变。11号染色体三体在血液系统肿瘤中很少见，所有报告的11号染色体三体病例均被诊断为非淋巴细胞性肿瘤。在本报告中，讨论了真性红细胞增多症中染色体改变与白血病/MDS发生之间的相关性。