Veiga Ricardo Santana, Cassis João, Oliveira Pedro, Lopez-Beltran António
Anal Quant Cytopathol Histpathol. 2016 Feb;38(1):52-6.
Inverted papilloma (IP) is an unusual benign neoplasm, most commonly found in the bladder. Cases of malignant transformation have been reported in the past, although most of them are now considered to be urothelial carcinomas with an inverted growth pattern.
A 54-year-old man was diagnosed with urothelial carcinoma in situ (UCIS), high-grade papillary urothelial carcinoma (HGPUC), and IP by transurethral resection specimen of the bladder. The urothelial carcinoma cells were seen colonizing the inverted papilloma.
The coexistence of IP with UCIS and HGPUC is rare. Immunohistochemistry helps distinguish between IP and UC in difficult cases such as this one. A brief review of other reported cases of inverted papilloma coexisting with urothelial carcinoma in the English literature over the past 25 years is presented.
内翻性乳头状瘤（IP）是一种少见的良性肿瘤，最常见于膀胱。过去曾有恶变病例报道，不过现在大多数被认为是具有内翻生长模式的尿路上皮癌。
一名54岁男性经膀胱经尿道切除标本诊断为原位尿路上皮癌（UCIS）、高级别乳头状尿路上皮癌（HGPUC）和IP。可见尿路上皮癌细胞向内翻性乳头状瘤内浸润。
IP与UCIS和HGPUC并存的情况罕见。在这样的疑难病例中，免疫组化有助于鉴别IP和UC。本文简要回顾了过去25年英文文献中其他报道的内翻性乳头状瘤与尿路上皮癌并存的病例。
