使用富血小板纤维蛋白治疗双膦酸盐相关颌骨坏死。
Treatment of bisphosphonate-related osteonecrosis of the jaw using platelet-rich fibrin.
作者信息
Gönen Zeynep Burçin, Yılmaz Asan Canay
机构信息
a Genome and Stem Cell Center and Faculty of Dentistry, Department of Oral and Maxillofacial Surgery , Erciyes University , Kayseri , Turkey.
b Faculty of Dentistry, Department of Oral and Maxillofacial Surgery , Erciyes University , Kayseri , Turkey.
出版信息
Cranio. 2017 Sep;35(5):332-336. doi: 10.1080/08869634.2016.1203093. Epub 2016 Jun 30.
BACKGROUND
Bisphosphonates are commonly prescribed antiresorptive agents for the management of patients with osteoporosis, Paget's disease, multiple myeloma, and metastatic tumors. Platelet-rich fibrin (PRF) is a second generation platelet concentrate, and has the ability of regulating the inflammation and stimulation of chemotactic agents. The aim of this report is to present the treatment of Stage-3 bisphosphonate-related osteonecrosis of the jaw (BRONJ) by PRF.
CLINICAL PRESENTATION
A 77-year-old male patient with Stage-3 BRONJ was treated with minimal surgical operations and PRF membrane. The patient was followed up for 18 months, and there was no recurrence or exposure.
CONCLUSION
PRF may promote the healing of both bone and soft tissues even in Stage-3 patients. This technique is an alternative treatment modality for the closure of bone exposure and tissue healing in BRONJ patients.
背景
双膦酸盐是常用于治疗骨质疏松症、佩吉特病、多发性骨髓瘤和转移性肿瘤患者的抗吸收药物。富血小板纤维蛋白（PRF）是第二代血小板浓缩物，具有调节炎症和刺激趋化因子的能力。本报告旨在介绍用PRF治疗3期双膦酸盐相关颌骨坏死（BRONJ）。
临床表现
一名患有3期BRONJ的77岁男性患者接受了微创外科手术和PRF膜治疗。对该患者进行了18个月的随访，未出现复发或创口暴露情况。
结论
即使是3期患者，PRF也可能促进骨和软组织的愈合。该技术是BRONJ患者闭合骨创口和组织愈合的一种替代治疗方式。
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