军队中各类患者群体弓形虫感染的血清学诊断
SEROLOGICAL DIAGNOSIS OF TOXOPLASMA GONDII INFECTION IN VARIOUS PATIENT POPULATION IN THE ARMED FORCES.
作者信息
Praharaj C A, Singh S P, Chander C Y, Nagendra A
机构信息
Associate Professor, Department of Microbiology, Armed For es Medical College, Pune-411 040.
Advance Course Trainee (Pathology), Department of Microbiology, Armed For es Medical College, Pune-411 040.
出版信息
Med J Armed Forces India. 2001 Oct;57(4):298-301. doi: 10.1016/S0377-1237(01)80007-1. Epub 2011 Jul 21.
The study included 200 healthy age and sex matched controls (120 healthy volunteers and 80 healthy antenatal cases without any bad obstetric history) and 300 cases comprising patients with bad obstetric history (BOH) 80 cases, seizure or encephalitis 50 cases, cervical lymphadenopathy 30 cases, congenital deformity 30 cases, HIV infected 80 cases and patients on long term immunosuppression 30 cases. Anti-toxoplasma IgG & IgM were measured by ELISA and individuals found positive for anti Toxoplasma gondii IgM or with high titre of IgG were subjected to repeat testing after 3 weeks for rise in titre. True sero-prevalence of T gondii infection was found to be 19% and it increased with increasing age in the population. 2.33% patients were found to have acute toxoplasma infection. Statistical significance was seen only in patients with BOH and children born with congenital abnormality.
该研究纳入了200名年龄和性别匹配的健康对照者（120名健康志愿者和80名无不良产科病史的健康产前病例）以及300例患者，其中包括有不良产科病史（BOH）的患者80例、癫痫或脑炎患者50例、颈部淋巴结病患者30例、先天性畸形患者30例、HIV感染者80例以及长期接受免疫抑制治疗的患者30例。采用酶联免疫吸附测定法（ELISA）检测抗弓形虫IgG和IgM，抗弓形虫IgM检测呈阳性或IgG滴度高的个体在3周后接受复查以观察滴度升高情况。发现弓形虫感染的实际血清流行率为19%，且在该人群中随年龄增长而升高。发现2.33%的患者患有急性弓形虫感染。仅在有不良产科病史的患者和先天性异常患儿中观察到统计学意义。
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