CD34、血管内皮生长因子和p53在结直肠癌新生血管生成中的作用及其与疾病分期的相关性。
Role of CD34, vascular endothelial growth factor, and p53 in neoangiogenesis as correlated with stage of disease in colorectal carcinoma.
作者信息
Malik Ajay, Mishra R N, Fanthome B, Rao Ramesh, Patrikar S R
机构信息
Associate Professor, Department of Pathology, AFMC, Pune - 40.
Ex-Commanding Officer, INHS Kalyani.
出版信息
Med J Armed Forces India. 2011 Oct;67(4):320-5. doi: 10.1016/S0377-1237(11)60076-2. Epub 2011 Oct 22.
BACKGROUND
Angiogenesis is critical for the growth of colorectal carcinoma (CRC). Vascular endothelial growth factor is the most important angiogenic growth factor.
METHOD
Fifty cases of CRC operated at INHS Asvini were studied by using immunohistochemical labelling of the tumours by using CD34, p53, and vascular endothelial growth factor (VEGF).
RESULTS
Out of the 50 cases, 31 (62%) were positive for p53; of which 80.7% showed high expression. Significant staining (> 20% tumour cells showing positivity) was seen in 33 patients (66%), while 34% were negative. Of the 33 positive cases, 57.58% showed high-grade VEGF positivity.
CONCLUSION
Vascular endothelial growth factor correlated significantly with the stage and grade of disease. Intra tumours microvessel density as calculated from CD34 expression increased with the stage and grade of the CRC.
背景
血管生成对结直肠癌（CRC）的生长至关重要。血管内皮生长因子是最重要的血管生成生长因子。
方法
通过使用CD34、p53和血管内皮生长因子（VEGF）对肿瘤进行免疫组织化学标记，研究了在INHS Asvini接受手术的50例CRC病例。
结果
在50例病例中，31例（62%）p53呈阳性；其中80.7%表现为高表达。33例患者（66%）可见显著染色（>20%肿瘤细胞呈阳性），而34%为阴性。在33例阳性病例中，57.58%表现为高级别VEGF阳性。
结论
血管内皮生长因子与疾病的分期和分级显著相关。根据CD34表达计算的肿瘤内微血管密度随CRC的分期和分级增加。
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