阿迪雅曼市地区的假性胆碱酯酶缺乏症

Pseudocholinesterase Enzyme Deficiency in Adıyaman City Area.

作者信息

Abdullayev Ruslan, Küçükebe Ömer Burak, Kaya Recai, Çelik Bülent, Kuşderci Hatice, Duran Mehmet, Uludağ Öznur, Öterkuş Mesut, Buyrukcan Aysel, Sabuncu Ülkü, Arpacı Abdullah

机构信息

Clinic of Anaesthesiology and Reanimation, Adıyaman University Training and Research Hospital, Adıyaman, Turkey.

Department of Biostatistics, Gazi University Faculty of Science, Ankara, Turkey.

出版信息

Turk J Anaesthesiol Reanim. 2015 Dec;43(6):381-6. doi: 10.5152/TJAR.2015.32848. Epub 2015 Dec 1.

DOI:10.5152/TJAR.2015.32848

PMID:27366534

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4894181/

Abstract

OBJECTIVE

Pseudocholinesterase (PChE) is an enzyme responsible for the hydrolysis of succinylcholine. In case of its deficiency, the effect of succinylcholine that is approximately 5-10 min is prolonged up to few hours. The use of succinylcholine has been declined recently. However, it is still actively used in some special conditions and in developing countries. In this study, incidence of PChE enzyme deficiency around Adiyaman city was investigated and presented with the literature review.

METHODS

After obtaining an approval from the investigational board of our hospital (Adiyaman University Medical School, Biomedical Research Ethics Board, 30.12.2012, Nr: B.30.2.ADY.0.20.00-600/51), patients undergoing any elective operation under general anaesthesia in the Adiyaman University Medical School Hospital between March and December 2013 were recruited for the study. After obtaining the patients' written consents, blood PChE, alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, creatinine, international normalisation ratio (INR) and activated partial thromboplastin time (aPTT) values of the patients were analysed. Possible association of the PChE deficiency with other values was also investigated. The normal value of PChE was taken as 4260-11250 for females aged 16-40 years and 5320-12920 U L(-1) for other patients.

RESULTS

The study was completed with 964 patients, 702 (72.8%) of whom were females. PChE enzyme levels were under the normal in 7.2% of the patients. There were no correlation between patient group, ALT, INR, aPTT and creatinine elevation with PChE deficiency (p>0.05), whereas AST and urea level elevation was significantly associated with PChE deficiency (p<0.05). The risk of PChE deficiency was 4.5 and 9 times higher in the patients with the elevation of AST and urea levels, respectively.

CONCLUSION

Pathological elevations of AST and urea that are a part of normal pre-operative biochemical analysis of blood will indicate the possible deficiency of PChE enzyme.

摘要

目的

假性胆碱酯酶（PChE）是一种负责水解琥珀酰胆碱的酶。在其缺乏的情况下，琥珀酰胆碱约5 - 10分钟的作用会延长至数小时。琥珀酰胆碱的使用近来有所减少。然而，它仍在一些特殊情况及发展中国家被积极使用。在本研究中，调查了阿迪亚曼市周边地区PChE酶缺乏的发生率，并结合文献综述进行了阐述。

方法

在获得我院（阿迪亚曼大学医学院，生物医学研究伦理委员会，2012年12月30日，编号：B.30.2.ADY.0.20.00 - 600/51）研究委员会的批准后，招募了2013年3月至12月期间在阿迪亚曼大学医学院医院接受任何全身麻醉下择期手术的患者参与研究。在获得患者书面同意后，分析患者的血液PChE、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、尿素、肌酐、国际标准化比值（INR）和活化部分凝血活酶时间（aPTT）值。还研究了PChE缺乏与其他值之间可能的关联。16 - 40岁女性的PChE正常值为4260 - 11250，其他患者为5320 - 12920 U L(-1)。

结果

该研究共纳入964例患者，其中702例（72.8%）为女性。7.2%的患者PChE酶水平低于正常。患者组、ALT、INR、aPTT及肌酐升高与PChE缺乏之间无相关性（p>0.05），而AST和尿素水平升高与PChE缺乏显著相关（p<0.05）。AST和尿素水平升高的患者中PChE缺乏风险分别高4.5倍和9倍。