一项基于社区的病例对照研究，旨在调查缺铁在甲状腺肿持续存在中的作用。

A community-based case-control study to investigate the role of iron deficiency in the persistence of goiter.

作者信息

Pathak Rambha, Chaudhary Chintu, Agarwalla Rashmi, Shaikh Zakirhusain, Goel R K D, Patvegar Bilkish

机构信息

Department of Community Medicine, Hamdard Institute of Medical Sciences and Research, New Delhi, India.

Department of Community Medicine, Adesh Institute of Medical Sciences and Research, Bhatinda, India.

出版信息

Indian J Endocrinol Metab. 2016 Jul-Aug;20(4):517-22. doi: 10.4103/2230-8210.183466.

DOI:10.4103/2230-8210.183466

PMID:27366719

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4911842/

Abstract

OBJECTIVES

To find out the magnitude of iron deficiency anemia in the age group of 6-12 years and investigate the role of iron deficiency as a possible contributor to endemic goiter in school children in Ambala.

MATERIALS AND METHODS

The present study was conducted as a subset of a cross-sectional study among 2700 children from 6 to 12 years of age to find out the prevalence of goiter. All the subjects who were found to be suffering from goiter in the cross-sectional study were enrolled in the case-control study as cases and were compared with age- and sex-matched controls (children without goiter) from the same cohort. The study was conducted from February 2011 to January 2012.

RESULTS

Out of total, goiter was observed in 12.6% of the subjects. Urinary iodine excretion was found to be <100 μg/L in 57 (10.5%) children. Mean hemoglobin (Hb) level of the study population was 11.9 g/dL. It was noted that 71% of the goitrous children had anemia (Hb <12 g/dL) as compared to 63.7% of the control group. Serum ferritin (SF) was <15 ng/mL in 70% of the children. The mean ± standard deviation of SF in the goitrous and nongoitrous children was 19.65 ± 32.51 μg/L and 27.55 ± 21.07 μg/L, respectively (P = 0.012).

CONCLUSION

The findings in the study suggest that iron deficiency anemia in children is contributing toward the persistence of goiter in the postiodization phase.

摘要

目的

了解6至12岁年龄组缺铁性贫血的严重程度，并调查缺铁作为安巴拉地区学龄儿童地方性甲状腺肿可能促成因素的作用。

材料与方法

本研究作为一项横断面研究的子研究进行，该横断面研究针对2700名6至12岁儿童以查明甲状腺肿的患病率。在横断面研究中所有被发现患有甲状腺肿的受试者作为病例纳入病例对照研究，并与来自同一队列的年龄和性别匹配的对照（无甲状腺肿的儿童）进行比较。研究于2011年2月至2012年1月进行。

结果

总体而言，12.6%的受试者观察到甲状腺肿。57名（10.5%）儿童的尿碘排泄量<100μg/L。研究人群的平均血红蛋白（Hb）水平为11.9g/dL。值得注意的是，71%的甲状腺肿儿童患有贫血（Hb<12g/dL），而对照组为63.7%。70%的儿童血清铁蛋白（SF）<15ng/mL。甲状腺肿儿童和非甲状腺肿儿童的SF的均值±标准差分别为19.65±32.51μg/L和27.55±21.07μg/L（P=0.012）。