针对心力衰竭的新型生物疗法：心肌修复
Novel Biological Therapies Targeting Heart Failure: Myocardial Rejuvenation.
作者信息
Favreau-Lessard Amanda J, Ryzhov Sergey, Sawyer Douglas B
机构信息
Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA.
Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME 04074, USA.
出版信息
Heart Fail Clin. 2016 Jul;12(3):461-71. doi: 10.1016/j.hfc.2016.03.008. Epub 2016 May 10.
Recovery of ventricular function occurs in a subset of patients with advanced heart failure treated with medical and/or mechanical therapy. Finding strategies that induce ventricular recovery through induction of repair, regeneration, or "rejuvenation" is a long-sought goal of research programs. Cell-based strategies, use of recombinant growth and survival factors, and gene delivery are under investigation. In this brief article we highlight a few of the biological approaches in development to treat heart failure.
在接受药物和/或机械治疗的晚期心力衰竭患者中，一部分患者的心室功能会有所恢复。通过诱导修复、再生或“年轻化”来促使心室恢复的策略，是研究项目长期以来追求的目标。基于细胞的策略、重组生长和存活因子的应用以及基因递送都在研究之中。在这篇简短的文章中，我们重点介绍了一些正在研发的治疗心力衰竭的生物学方法。
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