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基于隐形眼镜的眼压传感器

[Intraocular Pressure Sensor Based on a Contact Lens].

作者信息

Guo Xuhong, Pet Weihua, Yao Zhaolin, Chen Yuanfang, Hu Xiaohui, Chen Hongda, Zhu Jingyuan, Wu Huijuan

出版信息

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2016 Feb;33(1):18-22.

Abstract

Intraocular pressure detection has a great significance for understanding the status of eye health, prevention and treatment of diseases such as glaucoma. Traditional intraocular pressure detection needs to be held in the hospital. It is not only time-consuming to doctors and patients, but also difficult to achieve 24 hour-continuous detection. Microminiaturization of the intraocular pressure sensor and wearing it as a contact lens, which is convenient, comfortable and noninvasive, can solve this problem because the soft contact lens with an embedded micro fabricated strain gauge allows the measurement of changes in corneal curvature to correlate to variations of intraocular pressure. We fabricated a strain gauge using micro-electron mechanical systems, and integrated with the contact lens made of polydimethylsiloxane (PDMS) using injection molding. The experimental results showed that the sensitivity was 100. 7 µV/µm. When attached to the corneal surface, the average sensitivity of sensor response of intraocular pressure can be 125.8 µV/mm Hg under the ideal condition.

摘要

眼压检测对于了解眼部健康状况、预防和治疗青光眼等疾病具有重要意义。传统的眼压检测需要在医院进行。这不仅对医生和患者来说耗时,而且难以实现24小时连续检测。将眼压传感器微型化并制成隐形眼镜佩戴,既方便、舒适又无创,能够解决这个问题,因为嵌入微加工应变计的软性隐形眼镜可以通过测量角膜曲率的变化来关联眼压的变化。我们使用微机电系统制造了一个应变计,并通过注塑成型与由聚二甲基硅氧烷(PDMS)制成的隐形眼镜集成在一起。实验结果表明灵敏度为100.7 μV/μm。当附着在角膜表面时,在理想条件下传感器对眼压响应的平均灵敏度可达125.8 μV/mmHg。

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