健康个体中有无 ADHD 家族史者纹状体多巴胺转运体的可获得性。
Availability of Striatal Dopamine Transporter in Healthy Individuals With and Without a Family History of ADHD.
机构信息
1 Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan.
2 Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
出版信息
J Atten Disord. 2019 May;23(7):665-670. doi: 10.1177/1087054716654570. Epub 2016 Jul 7.
OBJECTIVE
ADHD is the most prevalent neurodevelopmental disorder. It is highly heritable and multifactorial, but the definitive causes remain unknown. Abnormal dopamine transporter (DAT) availability has been reported, but the data are inconsistent. The aim of this study was to examine whether DAT availability differs between healthy parents with and without ADHD offspring.
METHOD
Eleven healthy parents with ADHD offspring and 11 age- and sex-matched healthy controls without ADHD offspring were recruited. The availability of DAT was approximated using single-photon emission computed tomography, with [Tc] TRODAT-1 as the ligand.
RESULTS
DAT availability in the basal ganglia, caudate nucleus, and putamen was significantly lower in the parents with ADHD offspring than in the healthy controls without ADHD offspring.
CONCLUSION
The results suggest that ADHD could be heritable via abnormal DAT activities.
目的
ADHD 是最常见的神经发育障碍。它具有高度遗传性和多因素性，但确切原因仍不清楚。已有报道称多巴胺转运蛋白（DAT）的可用性存在异常，但数据不一致。本研究旨在探讨 ADHD 患儿的健康父母与无 ADHD 患儿的健康父母之间 DAT 的可用性是否存在差异。
方法
招募了 11 名 ADHD 患儿的健康父母和 11 名年龄和性别相匹配的无 ADHD 患儿的健康对照者。使用单光子发射计算机断层扫描（SPECT），[Tc] TRODAT-1 作为配体，来估计 DAT 的可用性。
结果
ADHD 患儿的健康父母的基底节、尾状核和壳核中的 DAT 可用性明显低于无 ADHD 患儿的健康对照者。
结论
研究结果提示，ADHD 可能通过 DAT 活性的异常遗传。
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