Cao Si-Fan, Hu Wen-Long, Wu Min-Min, Jiang Li-Yan
1 Department of Maternal, Child and Adolescent Health, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong, People's Republic of China.
2 Luohu Population & Family Planning Service Center, Shenzhen, Guangdong, People's Republic of China.
Reprod Sci. 2017 Mar;24(3):456-462. doi: 10.1177/1933719116657892. Epub 2016 Jul 20.
Polycystic ovary syndrome (PCOS) is a prevalent endocrinological disorder in reproductive-age women and is often associated with a metabolic syndrome. To investigate whether exercise intervention promotes PCOS prevention, a rat model was used. Polycystic ovary syndrome was induced by letrozole administration, and animals presented with obesity, sex hormone disorder, no ovulation, large cystic follicles, and increasing fasting insulin (FINS) and leptin levels. The intervention was set at 3 different intensities of swimming exercise: low (0.5 h/d), moderate (1 h/d), and high (2 h/d), and compared with a PCOS model group (letrozole administration without exercise intervention) and a control group. The exercise intervention in the low-intensity group did not produce changes in obesity, testosterone, progesterone (P), and follicle-stimulating hormone (FSH) levels. Moderate-intensity exercise reduced body weight, retained ovulation, and P levels were increased but remained lower than those in the control group. The FSH levels were significantly higher, and FINS and leptin levels were lower than in the model group ( P < 0.05) but not in the control group. The high-intensity group demonstrated the greatest effect of PCOS prevention. Testosterone, luteinizing hormone, FINS, and leptin levels were significantly lower in the high-intensity group, and FSH and P levels were higher compared with the model group. These results suggest that high-intensity exercise intervention can effectively prevent PCOS development.
多囊卵巢综合征（PCOS）是育龄女性中一种常见的内分泌紊乱疾病，常与代谢综合征相关。为了研究运动干预是否能促进PCOS的预防，使用了大鼠模型。通过给予来曲唑诱导多囊卵巢综合征，动物出现肥胖、性激素紊乱、无排卵、大的囊性卵泡以及空腹胰岛素（FINS）和瘦素水平升高。干预设置为3种不同强度的游泳运动：低强度（0.5小时/天）、中等强度（1小时/天）和高强度（2小时/天），并与PCOS模型组（给予来曲唑但无运动干预）和对照组进行比较。低强度组的运动干预在肥胖、睾酮、孕酮（P）和卵泡刺激素（FSH）水平方面未产生变化。中等强度运动降低了体重，保留了排卵功能，P水平升高但仍低于对照组。FSH水平显著更高，FINS和瘦素水平低于模型组（P<0.05）但不低于对照组。高强度组显示出预防PCOS的最大效果。与模型组相比，高强度组的睾酮、黄体生成素、FINS和瘦素水平显著降低，FSH和P水平更高。这些结果表明，高强度运动干预可以有效预防PCOS的发展。
