Casselholmde Salles Manuel, Kvanta Anders, Amrén Urban, Epstein David
Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT242-6. doi: 10.1167/iovs.15-18819.
To investigate the relationship between best-corrected visual acuity (BCVA) and the foveal avascular zone (FAZ) in patients with central retinal vein occlusion (CRVO) evaluated with optical coherence angiography (OCT-A).
The study was a prospective consecutive case series including 24 patients with CRVO. All patients received either aflibercept or ranibizumab intravitreal injections prior to analysis. Best-corrected visual acuity and FAZ were evaluated in eyes without macular edema. The FAZ areas were evaluated with OCT-A in both the superficial and deep capillary plexus layers by using 3 × 3-mm images of the macula. Disruption of the ellipsoid zone (EZ) was also analyzed.
The mean superficial FAZ area measured 0.76 mm2 (95% confidence interval [CI] 0.50-1.13). The mean deep FAZ area measured 1.12 mm2 (95% CI 0.77-1.47). In a multivariable analysis a negative correlation was found between the BCVA and the superficial FAZ area (r = -0.54, P = 0.03). The correlation between the BCVA and deep FAZ area did not meet statistical significance (r = -0.43, P = 0.09). In a multivariable analysis, disruption of the ellipsoid zone was significantly correlated to a larger superficial FAZ area (r = 0.68, P = <0.001) and poor visual acuity (r = 0.75, P < 0.001).
Optical coherence tomography-A is a novel technique that allows segmented evaluation of the FAZ in patients with CRVO providing additional prognostic information. The FAZ areas were enlarged both in the superficial and the deep capillary networks. A significant correlation was found between BCVA and the FAZ area in CRVO patients without macular edema (ClinicalTrials.gov, number NCT02274259).
利用光学相干血管造影（OCT-A）评估视网膜中央静脉阻塞（CRVO）患者的最佳矫正视力（BCVA）与黄斑无血管区（FAZ）之间的关系。
本研究为前瞻性连续病例系列，纳入24例CRVO患者。所有患者在分析前均接受了阿柏西普或雷珠单抗玻璃体腔内注射。对无黄斑水肿的眼睛评估最佳矫正视力和FAZ。通过使用黄斑区3×3毫米图像，在OCT-A下评估浅层和深层毛细血管丛层的FAZ面积。还分析了椭圆体带（EZ）的破坏情况。
测量的平均浅层FAZ面积为0.76平方毫米（95%置信区间[CI] 0.50 - 1.13）。平均深层FAZ面积为1.12平方毫米（95% CI 0.77 - 1.47）。在多变量分析中，发现BCVA与浅层FAZ面积之间存在负相关（r = -0.54，P = 0.03）。BCVA与深层FAZ面积之间的相关性未达到统计学意义（r = -0.43，P = 0.09）。在多变量分析中，椭圆体带的破坏与更大的浅层FAZ面积（r = 0.68，P = <0.001）和视力差（r = 0.75，P < 0.001）显著相关。
光学相干断层扫描血管造影是一种新技术，可对CRVO患者的FAZ进行分层评估，提供额外的预后信息。浅层和深层毛细血管网络中的FAZ面积均增大。在无黄斑水肿的CRVO患者中，发现BCVA与FAZ面积之间存在显著相关性（ClinicalTrials.gov，编号NCT02274259）。
