拮抗急性髓系白血病的自我更新：ID2 登台亮相。

Antagonizing Self-Renewal in Acute Myeloid Leukemia: ID2 Takes the Stage.

机构信息

Leukaemia Biology Laboratory, Cancer Research UK Manchester Institute, The University of Manchester, Manchester M20 4BX, UK.

出版信息

Cancer Cell. 2016 Jul 11;30(1):5-7. doi: 10.1016/j.ccell.2016.06.006.

DOI:10.1016/j.ccell.2016.06.006

PMID:27411580

Abstract

E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukemia.

摘要

E 蛋白及其功能拮抗物 ID 蛋白在正常造血中具有重要作用。在本期《癌细胞》杂志中，Ghisi 等人表明，高水平的 ID2 拮抗自我更新并促进白血病干细胞在 MLL 易位的急性髓系白血病分子亚型中的分化。