年轻和老年患者肾肿瘤的临床病理结果有差异吗？一项多中心配对分析。
Is there a difference in clinicopathological outcomes of renal tumor between young and old patients? A multicenter matched-pair analysis.
作者信息
Kim Jeong Ho, Park Yong Hyun, Kim Yong June, Kang Seok Ho, Byun Seok Soo, Hong Sung-Hoo
机构信息
a Department of Urology , Dongnam Institute of Radiological & Medical Sciences, Cancer Center , Busan , Republic of Korea ;
b Department of Urology , Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea , Seoul , Republic of Korea ;
出版信息
Scand J Urol. 2016 Oct;50(5):387-91. doi: 10.1080/21681805.2016.1204621. Epub 2016 Jul 14.
OBJECTIVE
The aim of this study was to investigate the influence of age at diagnosis on tumor characteristics and cancer-specific survival (CSS) in renal cell carcinoma (RCC).
MATERIALS AND METHODS
Data of patients who underwent radical or partial nephrectomy for renal tumor between 2003 and 2011 at multiple institutions were collected. Patients were divided into two groups according to age at diagnosis: 20-39 years and 40-79 years. To adjust for potential baseline confounders, propensity score matching was performed.
RESULTS
All included data showed that young RCC patients presented with renal tumors that had a more favorable histological subtype, were localized, smaller in size, and had a lower Fuhrman nuclear grade. The 5 year CSS rates were 95.5% and 90.5% in the young and old patient groups, respectively (log rank p = 0.019). After matching on the propensity score, the two groups with RCC had 302 patients each. Because the groups were matched on covariates, there were no significant differences in the pathological proportion, tumor size, Fuhrman nuclear grade and clinical T stage. The 5 year CSS rates were 95.5% and 94.7% in the young and old patient groups, respectively (log rank p = 0.184).
CONCLUSION
After adjusting for potential biases, there was no significant difference in prognosis between young and old patients with RCC.
目的
本研究旨在探讨诊断时年龄对肾细胞癌（RCC）肿瘤特征及癌症特异性生存（CSS）的影响。
材料与方法
收集了2003年至2011年期间多家机构因肾肿瘤接受根治性或部分肾切除术患者的数据。根据诊断时年龄将患者分为两组：20 - 39岁组和40 - 79岁组。为调整潜在的基线混杂因素，进行了倾向评分匹配。
结果
所有纳入数据显示，年轻的RCC患者所患肾肿瘤具有更有利的组织学亚型，为局限性肿瘤，体积较小，且Fuhrman核分级较低。年轻和老年患者组的5年CSS率分别为95.5%和90.5%（对数秩检验p = 0.019）。在倾向评分匹配后，两组RCC患者各有302例。由于两组在协变量上进行了匹配，病理比例、肿瘤大小、Fuhrman核分级和临床T分期均无显著差异。年轻和老年患者组的5年CSS率分别为95.5%和94.7%（对数秩检验p = 0.184）。
结论
在调整潜在偏倚后，年轻和老年RCC患者的预后无显著差异。
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