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一项关于原发性多汗症内镜胸交感神经切断术后生活质量的前瞻性队列研究。

A Prospective Cohort Study on Quality of Life after Endoscopic Thoracic Sympathectomy for Primary Hyperhidrosis.

作者信息

Dharmaraj B, Kosai N R, Gendeh H, Ramzisham A R, Das S

机构信息

Medical Officer, Minimally Invasive and Upper Gastrointestinal Unit, Department of Surgery, Universiti Kebangsaan Malaysia Medical Centre, Malaysia.

Associate Professor in Upper GI Surgery, Senior Consultant General Surgeon, Minimally Invasive and Upper Gastrointestinal Unit, Department of Surgery, Universiti Kebangsaan Malaysia Medical Centre, Malaysia.

出版信息

Clin Ter. 2016 May-Jun;167(3):67-71. doi: 10.7417/CT.2016.1928.

Abstract

BACKGROUND

Hyperhidrosis is an excessive sweating disorder affecting quality of life. Endoscopic thoracic sympathectomy (ETS), introduced by Kux in 1951, is currently the gold standard surgical treatment for primary hyperhidrosis. 75% of patients with primary hyperhidrosis have seen improvement in quality of life within 30 days after surgery. Compensatory hyperhidrosis and pneumothorax (up to 75%) have been reported in patients after surgery. This study evaluates the functional status, self- esteem, compensatory hyperhidrosis and quality of life among patient with primary hyperhidrosis before and after undergoing ETS.

METHOD

Fifty (n=50) patients between the ages 18 to 30, with primary hyperhidrosis were recruited. Patients answered the quality of life questionnaire and Rosenberg self-esteem questionnaire prior to surgery and 30 days post surgery on follow up. Any post-operative complications were documented. Telephone interviews were held for patients who were unable to attend the clinics for follow-up.

RESULTS

Forty six patients (92%) had symptomatic relieve within 30 days of surgery. The incidence of compensatory sweating was 78% (39 patients), with 6 patients developing severe hyperhidrosis. Two patients who did not experience symptomatic relieve, developed compensatory hyperhidrosis. Pneumothorax was documented in 8 patients (16%), with 6 patients requiring chest tubes. Significant improvement in quality of life and self-esteem was seen among patients after surgery.

CONCLUSIONS

ETS has shown to significantly improve the quality of life and self-esteem of patients with primary hyperhidrosis within 30 days of surgery. However, the rate of compensatory hyperhidrosis still remains high (78%) which requires a long term evaluation.

摘要

背景

多汗症是一种影响生活质量的过度出汗疾病。1951年库克斯引入的内镜胸交感神经切除术(ETS)是目前原发性多汗症的金标准外科治疗方法。75%的原发性多汗症患者在术后30天内生活质量得到改善。术后患者中曾报告有代偿性多汗症和气胸(发生率高达75%)。本研究评估原发性多汗症患者在接受ETS手术前后的功能状态、自尊、代偿性多汗症和生活质量。

方法

招募了50名年龄在18至30岁之间的原发性多汗症患者。患者在手术前和术后30天随访时回答生活质量问卷和罗森伯格自尊问卷。记录任何术后并发症。对无法到诊所进行随访的患者进行电话访谈。

结果

46名患者(92%)在术后30天内症状缓解。代偿性出汗的发生率为78%(39名患者),其中6名患者出现严重多汗症。2名未经历症状缓解的患者出现了代偿性多汗症。8名患者(16%)记录到气胸,其中6名患者需要放置胸管。术后患者的生活质量和自尊有显著改善。

结论

ETS已显示在手术30天内可显著改善原发性多汗症患者的生活质量和自尊。然而,代偿性多汗症的发生率仍然很高(78%),这需要长期评估。

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