Domenici L, Monti M, Bracchi C, Giorgini M, Colagiovanni V, Muzii L, Benedetti Panici P
Department of Gynecological Obstetrics and Urologic Sciences, University Sapienza of Rome, Rome, Italy.
Eur Rev Med Pharmacol Sci. 2016 Jul;20(13):2920-5.
Urinary tract infections still represent a significant bother for women and result in high costs to the health system. D-mannose is a simple sugar; it seems able to hinder bacteria adhesion to the urothelium. The present study aimed to determine whether D-mannose alone is effective in treating acute urinary tract infections in women and its possible utility in the management of recurrences.
This is a pilot study, performed between April 2014 and July 2015 at Department of Gynaecological Obstetrics and Urologic Sciences of "Sapienza" University of Rome. A D-mannose compound was administered twice daily for 3 days and then once a day for 10 days. Changes in patients' symptoms, the therapeutic effects and changes in quality of life (QoL) were evaluated clinically and using a specifically validated questionnaire (UTISA). After described treatment, patients were randomized in receiving or not prophylaxis in the next 6 months.
Mean UTISA scores recorded after completing the treatment, compared with baseline scores, showed a significant improvement of the majority of symptoms (p < 0.05). D-mannose seemed to have had a significant positive effect on UTIs' resolution and QoL improvement (p = 0.0001). As prophylactic agent administered for 6 months, it showed promising results (4.5% vs. 33.3% recurrences in treated and untreated patients respectively).
The results of this study suggest that D-mannose can be an effective aid in acute cystitis management and also a successful prophylactic agent in a selected population; however, more studies will certainly be needed to confirm the results of our pilot study.
尿路感染仍是困扰女性的一个重要问题，给卫生系统带来高昂成本。D-甘露糖是一种单糖；它似乎能够阻碍细菌黏附于尿道上皮。本研究旨在确定单独使用D-甘露糖治疗女性急性尿路感染是否有效及其在预防复发方面的潜在效用。
这是一项前瞻性研究，于2014年4月至2015年7月在罗马“萨皮恩扎”大学妇产科与泌尿科学系开展。一种D-甘露糖化合物每天服用两次，共服用3天，之后每天服用一次，共服用10天。通过临床评估及使用一份经过专门验证的问卷（UTISA）来评估患者症状的变化、治疗效果及生活质量（QoL）的变化。在上述治疗结束后，患者被随机分为在接下来6个月接受或不接受预防治疗两组。
完成治疗后记录的平均UTISA评分与基线评分相比，多数症状有显著改善（p < 0.05）。D-甘露糖似乎对尿路感染的缓解及生活质量的改善有显著的积极影响（p = 0.0001）。作为服用6个月的预防药物，它显示出了有前景的结果（治疗组和未治疗组的复发率分别为4.5%和33.3%）。
本研究结果表明，D-甘露糖在急性膀胱炎的治疗中可能是一种有效的辅助手段，在特定人群中也是一种成功的预防药物；然而，肯定需要更多研究来证实我们这项前瞻性研究的结果。
