Woo Kyong-Je, Kang Bo Young, Min Jeong Jin, Park Jin-Woo, Kim Ara, Oh Kap Sung
Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Department of Anesthesiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
J Plast Reconstr Aesthet Surg. 2016 Sep;69(9):1203-10. doi: 10.1016/j.bjps.2016.06.026. Epub 2016 Jul 9.
Children with microtia complain of severe postoperative pain during early postoperative days after rib cartilage harvest for auricular reconstruction. The purpose of this study was to evaluate the effects of preventive donor site wound analgesia by intercostal nerve block (ICNB) and catheter-based infusion of local analgesics on postoperative pain after rib cartilage graft for auricular reconstruction in children with microtia.
In this prospective randomized study, 66 children underwent postoperative pain control using either preventive ICNB followed by catheter-based infusion (33 patients, study group) or intravenous (IV) analgesia alone (33 patients, control group). ICNB was performed under direct vision by the surgeon by injecting 0.5% bupivacaine into each of the three intercostal spaces before perichondrial dissection. Catheters were placed in three subchondral spaces before wound closure, and 0.5% bupivacaine was infused every 12 h for 48 h postoperatively. Pain degrees were recorded every 4 h during the first 48 postoperative hours using a visual analogue scale.
The study group showed significantly lower mean pain scores of the chest at rest (3.7 vs. 5.1, p = 0.001), the chest during coughing (4.3 vs. 5.8, p = 0.006), and the ear (3.0 vs. 4.1, p = 0.001) than the control group. The amount of use of rescue IV ketorolac was smaller in the study group (p = 0.026) than in the control group. No side effects related to the intervention were noted.
Preventive ICNB followed by catheter-based infusion is effective and safe in postoperative pain relief in rib cartilage graft for auricular reconstruction. (The clinical trial registration number: WHO ICTRP, apps.who.int/trialsearch (KCT0001668)).
小耳畸形患儿在肋软骨取材用于耳廓再造术后早期会抱怨严重的术后疼痛。本研究的目的是评估肋间神经阻滞(ICNB)联合导管局部镇痛对小耳畸形患儿耳廓再造术后肋软骨取材供区伤口预防性镇痛的效果。
在这项前瞻性随机研究中,66例患儿采用预防性ICNB联合导管局部镇痛(33例,研究组)或单纯静脉镇痛(33例,对照组)进行术后疼痛控制。ICNB由外科医生在直视下于软骨膜剥离前向三个肋间间隙各注射0.5%布比卡因。在伤口闭合前于三个软骨下间隙放置导管,术后每12小时输注0.5%布比卡因,共48小时。术后48小时内每4小时使用视觉模拟评分记录疼痛程度。
研究组静息时胸部、咳嗽时胸部及耳部的平均疼痛评分显著低于对照组,分别为3.7对5.1(p = 0.001)、4.3对5.8(p = 0.006)、3.0对4.1(p = 0.001)。研究组补救性静脉注射酮咯酸的用量少于对照组(p = 0.026)。未观察到与干预相关的副作用。
预防性ICNB联合导管局部镇痛对耳廓再造肋软骨取材术后疼痛缓解有效且安全。(临床试验注册号:WHO ICTRP,apps.who.int/trialsearch (KCT0001668))