干燥综合征中的多自身免疫现象。
Polyautoimmunity in Sjögren Syndrome.
作者信息
Anaya Juan-Manuel, Rojas-Villarraga Adriana, Mantilla Ruben D, Arcos-Burgos Mauricio, Sarmiento-Monroy Juan Camilo
机构信息
Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 26 No. 63B-51, Bogotá 111221, Colombia.
Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Carrera 26 No. 63B-51, Bogotá 111221, Colombia.
出版信息
Rheum Dis Clin North Am. 2016 Aug;42(3):457-72. doi: 10.1016/j.rdc.2016.03.005. Epub 2016 Jun 21.
Polyautoimmunity is defined as the presence of more than one well-defined autoimmune disease (AD) in a single patient. Polyautoimmunity is a frequent condition in Sjögren syndrome (SS) and follows a grouping pattern. The most frequent ADs observed in SS are autoimmune thyroid disease, rheumatoid arthritis, and systemic lupus erythematosus. Main factors associated with polyautoimmunity in SS are tobacco smoking and some genetic variants. The study of polyautoimmunity provides important clues for elucidating the common mechanisms of autoimmne diseases (ie, the autoimmune tautology).
多自身免疫性被定义为单个患者存在一种以上明确的自身免疫性疾病（AD）。多自身免疫性在干燥综合征（SS）中很常见，且呈现一种聚集模式。在SS中观察到的最常见的自身免疫性疾病是自身免疫性甲状腺疾病、类风湿性关节炎和系统性红斑狼疮。与SS中的多自身免疫性相关的主要因素是吸烟和一些基因变异。对多自身免疫性的研究为阐明自身免疫性疾病的共同机制（即自身免疫同义反复）提供了重要线索。
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