罕见的肾脏过敏反应：西他列汀诱发的急性肾小管间质性肾炎。

Rare allergic reaction of the kidney: sitagliptin-induced acute tubulointerstitial nephritis.

作者信息

Alsaad Ali A, Dhannoon Sarah M, Pantin Sally-Ann L, Porter Ivan E

机构信息

Department of Internal Medicine, Mayo Clinic Florida, Jacksonville, Florida, USA.

Department of Internal Medicine, University of Central Florida, Orlando, Florida, USA.

出版信息

BMJ Case Rep. 2016 Jul 19;2016:bcr2016216297. doi: 10.1136/bcr-2016-216297.

DOI:10.1136/bcr-2016-216297

PMID:27436034

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4964118/

Abstract

A 56-year-old man with a history of diabetes mellitus type-2 and stage-2 chronic kidney disease secondary to diabetic nephropathy presented with an acute deterioration of kidney function. Non-invasive work-up failed to reveal the underlying aetiology for the acute kidney failure. Kidney biopsy revealed acute tubulointerstitial nephritis (ATIN) which was attributed to sitagliptin use. Only few case reports have shown this correlation. Our aim is to alert physicians and other providers of the potential effect of sitagliptin to cause ATIN with this biopsy-proven case.

摘要

一名56岁男性，有2型糖尿病病史，继发于糖尿病肾病的2期慢性肾脏病，出现肾功能急性恶化。无创检查未能揭示急性肾衰竭的潜在病因。肾活检显示为急性肾小管间质性肾炎（ATIN），归因于使用西他列汀。仅有少数病例报告显示了这种相关性。我们的目的是通过这个活检证实的病例提醒医生和其他医疗人员注意西他列汀导致ATIN的潜在影响。