Loitz B J, Zernicke R F, Vailas A C, Kody M H, Meals R A
Department of Kinesiology, University of California, Los Angeles 90024-1568.
Clin Orthop Relat Res. 1989 Jul(244):265-71.
Little work has been done on the effect that continuous passive motion (CPM) may have on maintaining the mechanical and biochemical characteristics of tendons deprived of normal load-bearing stimuli. This study compared changes in mechanical properties and collagen concentrations of the tibialis anterior tendon between two groups of rabbits: control animals that received no treatment and experimental animals that received CPM to one ankle and immobilization to the other. Treatment duration was three weeks. Mechanical testing yielded values for elastic modulus, stiffness, stress, strain, and strain energy density at linear and maximum loads. Hydroxyproline concentrations were measured to determine tendon collagen content. Findings indicated that cyclic tensile loading of tendons by CPM lessened the harmful effects of immobilization. Linear load and stress for CPM and control tendons were similar, while the same measures for immobilized tendons were 16% and 25% less than control tendons. Ultimate strength of the control tendons, however, exceeded CPM tendons by 16% and immobilized tendons by 20%. Hydroxyproline levels were comparable for the CPM, control, and immobilized tissues. For a short duration (three weeks), CPM reduced the detrimental effects of immobilization in the tendon, primarily in the linear-load region.
关于持续被动运动（CPM）对维持缺乏正常负重刺激的肌腱的机械和生化特性可能产生的影响，目前所做的研究很少。本研究比较了两组兔子胫前肌腱的力学性能和胶原蛋白浓度的变化：未接受治疗的对照动物，以及一侧踝关节接受CPM而另一侧踝关节固定的实验动物。治疗持续时间为三周。力学测试得出了线性和最大负荷下的弹性模量、刚度、应力、应变和应变能密度值。测量羟脯氨酸浓度以确定肌腱胶原蛋白含量。研究结果表明，CPM对肌腱的循环拉伸负荷减轻了固定的有害影响。CPM组和对照组肌腱的线性负荷和应力相似，而固定组肌腱的相同测量值分别比对照组肌腱低16%和25%。然而，对照肌腱的极限强度比CPM组肌腱高16%，比固定组肌腱高20%。CPM组、对照组和固定组组织的羟脯氨酸水平相当。在短时间内（三周），CPM减轻了肌腱固定的有害影响，主要是在线性负荷区域。
