Alves José Roberto, Silva Rodrigo do Carmo, Guerra Sâmea Costa Pinheiro, Freitas Tiago Tavares de, Souza Dyego Leandro Bezerra de, Amico Enio Campos
Departamento de Medicina Integrada, Faculdade de Medicina, Universidade Federal do Rio Grande do Norte, RN, Brasil.
Faculdade de Medicina, Universidade Federal do Rio Grande do Norte, RN, Brasil.
Arq Gastroenterol. 2016 Jul-Sep;53(3):156-62. doi: 10.1590/S0004-28032016000300007.
Bactibilia has several consequences to human health.
Assessing the bile microbiology of patients with biliopancreatic diseases in order to identify bacteria and their possible infectious complications.
Retrospective study of 30 bile culture samples from patients with benign and malignant biliopancreatic diseases. The samples were assessed to set the bile microbiological flora and to search for its possible link with comorbidity, carcinogenesis and postoperative infectious complications.
Thirty bile samples from patients at mean age ≈57.7 years, mostly female (n=18), were assessed. Bactibilia was found in 12 cases, mostly in patients with benign diseases (n=8), older than 50 years (n=23) and female (n=10). Adenocarcinoma of the duodenal papilla (n=9) and cholelithiasis (n=8) were the most common diseases. Escherichia coli (n=5) and Klebsiella sp (n=3) were predominantly found in patients with benign diseases; and Klebsiella sp (n=2) and Streptococcus sp (n=2) were prevalent in cancer patients. There were postoperative infectious complications in seven cases, five of them in bactibilia-associated patients (P=0.084).
Bactibilia was found in 12 samples and Escherichia coli and Klebsiella sp were most often identified in patients with benign diseases, as well as Streptococcus sp and Klebsiella sp in cancer patients. There was a trend of higher postoperative infectious complication incidence in patients with bactibilia.
胆系感染对人类健康有多种影响。
评估胆胰疾病患者的胆汁微生物群，以鉴定细菌及其可能的感染性并发症。
对30例患有良性和恶性胆胰疾病患者的胆汁培养样本进行回顾性研究。对样本进行评估，以确定胆汁微生物菌群，并寻找其与合并症、致癌作用和术后感染性并发症之间的可能联系。
评估了平均年龄约57.7岁患者的30份胆汁样本，其中大多数为女性（n = 18）。12例发现有胆系感染，大多为患有良性疾病的患者（n = 8）、年龄大于50岁的患者（n = 23）和女性患者（n = 10）。十二指肠乳头腺癌（n = 9）和胆结石（n = 8）是最常见的疾病。良性疾病患者中主要发现大肠杆菌（n = 5）和克雷伯菌属（n = 3）；癌症患者中克雷伯菌属（n = 2）和链球菌属（n = 2）较为普遍。7例出现术后感染性并发症，其中5例发生在胆系感染相关患者中（P = 0.084）。
12份样本中发现有胆系感染，良性疾病患者中最常鉴定出大肠杆菌和克雷伯菌属，癌症患者中则为链球菌属和克雷伯菌属。胆系感染患者术后感染性并发症发生率有升高趋势。
